Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson's disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that ex...

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Detalles Bibliográficos
Autores principales: Castedo, Maria, Lafarge, Antoine, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2023
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877585/
https://www.ncbi.nlm.nih.gov/pubmed/36743979
http://dx.doi.org/10.15698/cst2023.01.275
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author Castedo, Maria
Lafarge, Antoine
Kroemer, Guido
author_facet Castedo, Maria
Lafarge, Antoine
Kroemer, Guido
author_sort Castedo, Maria
collection PubMed
description The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson's disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhibition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging.
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spelling pubmed-98775852023-02-02 Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death Castedo, Maria Lafarge, Antoine Kroemer, Guido Cell Stress Viewpoint The deletion of the gene coding for poly(ADP-ribose) polymerase-1 (PARP1) or its pharmacological inhibition protects mice against cerebral ischemia and Parkinson's disease. In sharp contrast, PARP1 inhibitors are in clinical use for the eradication of vulnerable cancer cells. It appears that excessive PARP1 activation is involved in a specific cell death pathway called parthanatos, while inhibition of PARP1 in cancer cells amplifies DNA damage to a lethal level. Hence, PARP1 plays a context-dependent role in cell fate decisions. In addition, it appears that PARP1 plays an ambiguous role in organismal aging. Shared Science Publishers OG 2023-01-23 /pmc/articles/PMC9877585/ /pubmed/36743979 http://dx.doi.org/10.15698/cst2023.01.275 Text en Copyright: © 2023 Castedo et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Viewpoint
Castedo, Maria
Lafarge, Antoine
Kroemer, Guido
Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
title Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
title_full Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
title_fullStr Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
title_full_unstemmed Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
title_short Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death
title_sort poly(adp-ribose) polymerase-1 and its ambiguous role in cellular life and death
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877585/
https://www.ncbi.nlm.nih.gov/pubmed/36743979
http://dx.doi.org/10.15698/cst2023.01.275
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