Humoral response to mRNA‐based COVID‐19 vaccine in patients with immune thrombocytopenia

Data for COVID‐19 vaccine response in patients with immune thrombocytopenia (ITP) are very limited. In a study of 28 patients with ITP, anti‐severe acute respiratory syndrome coronavirus 2 spike antibody titres were measured after vaccination. The seroconversion rate for ITP patients was 91.3%, comp...

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Autores principales: Mori, Akio, Onozawa, Masahiro, Kobayashi, Mirei, Tsukamoto, Shihori, Senjo, Hajime, Ishio, Takashi, Yokoyama, Emi, Izumiyama, Koh, Saito, Makoto, Muraki, Haruna, Morioka, Masanobu, Teshima, Takanori, Kondo, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877767/
https://www.ncbi.nlm.nih.gov/pubmed/36442510
http://dx.doi.org/10.1111/bjh.18578
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author Mori, Akio
Onozawa, Masahiro
Kobayashi, Mirei
Tsukamoto, Shihori
Senjo, Hajime
Ishio, Takashi
Yokoyama, Emi
Izumiyama, Koh
Saito, Makoto
Muraki, Haruna
Morioka, Masanobu
Teshima, Takanori
Kondo, Takeshi
author_facet Mori, Akio
Onozawa, Masahiro
Kobayashi, Mirei
Tsukamoto, Shihori
Senjo, Hajime
Ishio, Takashi
Yokoyama, Emi
Izumiyama, Koh
Saito, Makoto
Muraki, Haruna
Morioka, Masanobu
Teshima, Takanori
Kondo, Takeshi
author_sort Mori, Akio
collection PubMed
description Data for COVID‐19 vaccine response in patients with immune thrombocytopenia (ITP) are very limited. In a study of 28 patients with ITP, anti‐severe acute respiratory syndrome coronavirus 2 spike antibody titres were measured after vaccination. The seroconversion rate for ITP patients was 91.3%, comparable to that in healthy controls (HCs). However, the antibody titre in ITP patients was significantly lower than that in HCs and declined with ageing. Furthermore, the antibody titre in ITP patients who received a minimum prednisolone dose of at least 5 mg/day at any time‐point at or after initial vaccination was lower than that in other patients.
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spelling pubmed-98777672023-01-26 Humoral response to mRNA‐based COVID‐19 vaccine in patients with immune thrombocytopenia Mori, Akio Onozawa, Masahiro Kobayashi, Mirei Tsukamoto, Shihori Senjo, Hajime Ishio, Takashi Yokoyama, Emi Izumiyama, Koh Saito, Makoto Muraki, Haruna Morioka, Masanobu Teshima, Takanori Kondo, Takeshi Br J Haematol Short Reports Data for COVID‐19 vaccine response in patients with immune thrombocytopenia (ITP) are very limited. In a study of 28 patients with ITP, anti‐severe acute respiratory syndrome coronavirus 2 spike antibody titres were measured after vaccination. The seroconversion rate for ITP patients was 91.3%, comparable to that in healthy controls (HCs). However, the antibody titre in ITP patients was significantly lower than that in HCs and declined with ageing. Furthermore, the antibody titre in ITP patients who received a minimum prednisolone dose of at least 5 mg/day at any time‐point at or after initial vaccination was lower than that in other patients. John Wiley and Sons Inc. 2022-11-28 /pmc/articles/PMC9877767/ /pubmed/36442510 http://dx.doi.org/10.1111/bjh.18578 Text en © 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Short Reports
Mori, Akio
Onozawa, Masahiro
Kobayashi, Mirei
Tsukamoto, Shihori
Senjo, Hajime
Ishio, Takashi
Yokoyama, Emi
Izumiyama, Koh
Saito, Makoto
Muraki, Haruna
Morioka, Masanobu
Teshima, Takanori
Kondo, Takeshi
Humoral response to mRNA‐based COVID‐19 vaccine in patients with immune thrombocytopenia
title Humoral response to mRNA‐based COVID‐19 vaccine in patients with immune thrombocytopenia
title_full Humoral response to mRNA‐based COVID‐19 vaccine in patients with immune thrombocytopenia
title_fullStr Humoral response to mRNA‐based COVID‐19 vaccine in patients with immune thrombocytopenia
title_full_unstemmed Humoral response to mRNA‐based COVID‐19 vaccine in patients with immune thrombocytopenia
title_short Humoral response to mRNA‐based COVID‐19 vaccine in patients with immune thrombocytopenia
title_sort humoral response to mrna‐based covid‐19 vaccine in patients with immune thrombocytopenia
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877767/
https://www.ncbi.nlm.nih.gov/pubmed/36442510
http://dx.doi.org/10.1111/bjh.18578
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