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Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation

The γδT cells that produce IL-17 (γδT17 cells) play a key role in various pathophysiologic processes in host defense and homeostasis. The development of γδT cells in the thymus requires γδT cell receptor (γδTCR) signaling mediated by the spleen tyrosine kinase (Syk) family proteins, Syk and Zap70. H...

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Detalles Bibliográficos
Autores principales:	Muro, Ryunosuke, Narita, Tomoya, Nitta, Takeshi, Takayanagi, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878111/ https://www.ncbi.nlm.nih.gov/pubmed/36713401 http://dx.doi.org/10.3389/fimmu.2022.1045881

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