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Genetically engineered pigs for xenotransplantation: Hopes and challenges
The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation. Most current studies mainly focus on genetically modifying organs or tissues from donor pigs to...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878146/ https://www.ncbi.nlm.nih.gov/pubmed/36712969 http://dx.doi.org/10.3389/fcell.2022.1093534 |
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author | Xi, Jiahui Zheng, Wei Chen, Min Zou, Qingjian Tang, Chengcheng Zhou, Xiaoqing |
author_facet | Xi, Jiahui Zheng, Wei Chen, Min Zou, Qingjian Tang, Chengcheng Zhou, Xiaoqing |
author_sort | Xi, Jiahui |
collection | PubMed |
description | The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation. Most current studies mainly focus on genetically modifying organs or tissues from donor pigs to reduce or prevent attack by the human immune system. Another potential organ source is interspecies chimeras. In this paper, we reviewed the progress of the genetically engineered pigs from the view of immunologic barriers and strategies, and discussed the possibility and challenges of the interspecies chimeras. |
format | Online Article Text |
id | pubmed-9878146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98781462023-01-27 Genetically engineered pigs for xenotransplantation: Hopes and challenges Xi, Jiahui Zheng, Wei Chen, Min Zou, Qingjian Tang, Chengcheng Zhou, Xiaoqing Front Cell Dev Biol Cell and Developmental Biology The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation. Most current studies mainly focus on genetically modifying organs or tissues from donor pigs to reduce or prevent attack by the human immune system. Another potential organ source is interspecies chimeras. In this paper, we reviewed the progress of the genetically engineered pigs from the view of immunologic barriers and strategies, and discussed the possibility and challenges of the interspecies chimeras. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9878146/ /pubmed/36712969 http://dx.doi.org/10.3389/fcell.2022.1093534 Text en Copyright © 2023 Xi, Zheng, Chen, Zou, Tang and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Xi, Jiahui Zheng, Wei Chen, Min Zou, Qingjian Tang, Chengcheng Zhou, Xiaoqing Genetically engineered pigs for xenotransplantation: Hopes and challenges |
title | Genetically engineered pigs for xenotransplantation: Hopes and challenges |
title_full | Genetically engineered pigs for xenotransplantation: Hopes and challenges |
title_fullStr | Genetically engineered pigs for xenotransplantation: Hopes and challenges |
title_full_unstemmed | Genetically engineered pigs for xenotransplantation: Hopes and challenges |
title_short | Genetically engineered pigs for xenotransplantation: Hopes and challenges |
title_sort | genetically engineered pigs for xenotransplantation: hopes and challenges |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878146/ https://www.ncbi.nlm.nih.gov/pubmed/36712969 http://dx.doi.org/10.3389/fcell.2022.1093534 |
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