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Genetically engineered pigs for xenotransplantation: Hopes and challenges

The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation. Most current studies mainly focus on genetically modifying organs or tissues from donor pigs to...

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Autores principales: Xi, Jiahui, Zheng, Wei, Chen, Min, Zou, Qingjian, Tang, Chengcheng, Zhou, Xiaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878146/
https://www.ncbi.nlm.nih.gov/pubmed/36712969
http://dx.doi.org/10.3389/fcell.2022.1093534
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author Xi, Jiahui
Zheng, Wei
Chen, Min
Zou, Qingjian
Tang, Chengcheng
Zhou, Xiaoqing
author_facet Xi, Jiahui
Zheng, Wei
Chen, Min
Zou, Qingjian
Tang, Chengcheng
Zhou, Xiaoqing
author_sort Xi, Jiahui
collection PubMed
description The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation. Most current studies mainly focus on genetically modifying organs or tissues from donor pigs to reduce or prevent attack by the human immune system. Another potential organ source is interspecies chimeras. In this paper, we reviewed the progress of the genetically engineered pigs from the view of immunologic barriers and strategies, and discussed the possibility and challenges of the interspecies chimeras.
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spelling pubmed-98781462023-01-27 Genetically engineered pigs for xenotransplantation: Hopes and challenges Xi, Jiahui Zheng, Wei Chen, Min Zou, Qingjian Tang, Chengcheng Zhou, Xiaoqing Front Cell Dev Biol Cell and Developmental Biology The shortage of donor resources has greatly limited the application of clinical xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ source for xenotransplantation. Most current studies mainly focus on genetically modifying organs or tissues from donor pigs to reduce or prevent attack by the human immune system. Another potential organ source is interspecies chimeras. In this paper, we reviewed the progress of the genetically engineered pigs from the view of immunologic barriers and strategies, and discussed the possibility and challenges of the interspecies chimeras. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9878146/ /pubmed/36712969 http://dx.doi.org/10.3389/fcell.2022.1093534 Text en Copyright © 2023 Xi, Zheng, Chen, Zou, Tang and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Xi, Jiahui
Zheng, Wei
Chen, Min
Zou, Qingjian
Tang, Chengcheng
Zhou, Xiaoqing
Genetically engineered pigs for xenotransplantation: Hopes and challenges
title Genetically engineered pigs for xenotransplantation: Hopes and challenges
title_full Genetically engineered pigs for xenotransplantation: Hopes and challenges
title_fullStr Genetically engineered pigs for xenotransplantation: Hopes and challenges
title_full_unstemmed Genetically engineered pigs for xenotransplantation: Hopes and challenges
title_short Genetically engineered pigs for xenotransplantation: Hopes and challenges
title_sort genetically engineered pigs for xenotransplantation: hopes and challenges
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878146/
https://www.ncbi.nlm.nih.gov/pubmed/36712969
http://dx.doi.org/10.3389/fcell.2022.1093534
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