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Case report: Clinical and virological characteristics of aseptic meningitis caused by a recombinant echovirus 18 in an immunocompetent adult

Echovirus 18 has been recognized as an important causative pathogen of aseptic meningitis in young children worldwide, and echovirus 18-induced meningitis is rarely found in adults with immunocompetence. In this case study, we report the clinical and virological characteristics of aseptic meningitis...

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Autores principales: Jiang, Chunmei, Xu, Zhixiang, Li, Jin, Zhang, Jiaqi, Xue, Xingkui, Jiang, Jingxia, Jiang, Guihua, Wang, Xisheng, Peng, Yun, Chen, Tian, Liu, Zhenzhen, Xie, Liu, Gao, Haibin, Liu, Yingxia, Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878155/
https://www.ncbi.nlm.nih.gov/pubmed/36714132
http://dx.doi.org/10.3389/fmed.2022.1094347
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author Jiang, Chunmei
Xu, Zhixiang
Li, Jin
Zhang, Jiaqi
Xue, Xingkui
Jiang, Jingxia
Jiang, Guihua
Wang, Xisheng
Peng, Yun
Chen, Tian
Liu, Zhenzhen
Xie, Liu
Gao, Haibin
Liu, Yingxia
Yang, Yang
author_facet Jiang, Chunmei
Xu, Zhixiang
Li, Jin
Zhang, Jiaqi
Xue, Xingkui
Jiang, Jingxia
Jiang, Guihua
Wang, Xisheng
Peng, Yun
Chen, Tian
Liu, Zhenzhen
Xie, Liu
Gao, Haibin
Liu, Yingxia
Yang, Yang
author_sort Jiang, Chunmei
collection PubMed
description Echovirus 18 has been recognized as an important causative pathogen of aseptic meningitis in young children worldwide, and echovirus 18-induced meningitis is rarely found in adults with immunocompetence. In this case study, we report the clinical and virological characteristics of aseptic meningitis caused by recombinant echovirus 18 in an adult with immunocompetence. A 31-year-old woman with immunocompetence was admitted to our hospital with fever, dizziness, severe headache, nausea, and vomiting for the past 1 day and was diagnosed with viral meningitis based on the clinical manifestations and laboratory results from cerebrospinal fluid (CSF). The patient received antiviral treatment with ribavirin and interferon as soon as the enterovirus infection was identified using qRT-PCR and was cured after 4 days. From the oropharyngeal swab and CSF samples, two echovirus 18 strains were isolated with a single nucleotide difference located at the 5′ UTR. Phylogenetic analyses based on the VP1 gene showed that the two strains belonged to the subgenotype C2 and were clustered with sequences obtained from China after 2015, while the results from the 3D polymerase region showed that the two strains were closely related to the E30 strains. Bootscanning results using the 5′ UTR to 2A region and the 2B to 3′ UTR region showed that potential intertypic recombination had occurred in the 2B gene. Recombination analyses further confirmed that the two strains (echovirus 18) presented genome recombination with echovirus 30 in the nucleotide regions of the 2B gene. To the best of our knowledge, this is the first report of echovirus 18-induced meningitis in an adult with immunocompetence from mainland China, highlighting the need for close surveillance of echovirus 18 both in children and adults in the future.
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spelling pubmed-98781552023-01-27 Case report: Clinical and virological characteristics of aseptic meningitis caused by a recombinant echovirus 18 in an immunocompetent adult Jiang, Chunmei Xu, Zhixiang Li, Jin Zhang, Jiaqi Xue, Xingkui Jiang, Jingxia Jiang, Guihua Wang, Xisheng Peng, Yun Chen, Tian Liu, Zhenzhen Xie, Liu Gao, Haibin Liu, Yingxia Yang, Yang Front Med (Lausanne) Medicine Echovirus 18 has been recognized as an important causative pathogen of aseptic meningitis in young children worldwide, and echovirus 18-induced meningitis is rarely found in adults with immunocompetence. In this case study, we report the clinical and virological characteristics of aseptic meningitis caused by recombinant echovirus 18 in an adult with immunocompetence. A 31-year-old woman with immunocompetence was admitted to our hospital with fever, dizziness, severe headache, nausea, and vomiting for the past 1 day and was diagnosed with viral meningitis based on the clinical manifestations and laboratory results from cerebrospinal fluid (CSF). The patient received antiviral treatment with ribavirin and interferon as soon as the enterovirus infection was identified using qRT-PCR and was cured after 4 days. From the oropharyngeal swab and CSF samples, two echovirus 18 strains were isolated with a single nucleotide difference located at the 5′ UTR. Phylogenetic analyses based on the VP1 gene showed that the two strains belonged to the subgenotype C2 and were clustered with sequences obtained from China after 2015, while the results from the 3D polymerase region showed that the two strains were closely related to the E30 strains. Bootscanning results using the 5′ UTR to 2A region and the 2B to 3′ UTR region showed that potential intertypic recombination had occurred in the 2B gene. Recombination analyses further confirmed that the two strains (echovirus 18) presented genome recombination with echovirus 30 in the nucleotide regions of the 2B gene. To the best of our knowledge, this is the first report of echovirus 18-induced meningitis in an adult with immunocompetence from mainland China, highlighting the need for close surveillance of echovirus 18 both in children and adults in the future. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9878155/ /pubmed/36714132 http://dx.doi.org/10.3389/fmed.2022.1094347 Text en Copyright © 2023 Jiang, Xu, Li, Zhang, Xue, Jiang, Jiang, Wang, Peng, Chen, Liu, Xie, Gao, Liu and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Jiang, Chunmei
Xu, Zhixiang
Li, Jin
Zhang, Jiaqi
Xue, Xingkui
Jiang, Jingxia
Jiang, Guihua
Wang, Xisheng
Peng, Yun
Chen, Tian
Liu, Zhenzhen
Xie, Liu
Gao, Haibin
Liu, Yingxia
Yang, Yang
Case report: Clinical and virological characteristics of aseptic meningitis caused by a recombinant echovirus 18 in an immunocompetent adult
title Case report: Clinical and virological characteristics of aseptic meningitis caused by a recombinant echovirus 18 in an immunocompetent adult
title_full Case report: Clinical and virological characteristics of aseptic meningitis caused by a recombinant echovirus 18 in an immunocompetent adult
title_fullStr Case report: Clinical and virological characteristics of aseptic meningitis caused by a recombinant echovirus 18 in an immunocompetent adult
title_full_unstemmed Case report: Clinical and virological characteristics of aseptic meningitis caused by a recombinant echovirus 18 in an immunocompetent adult
title_short Case report: Clinical and virological characteristics of aseptic meningitis caused by a recombinant echovirus 18 in an immunocompetent adult
title_sort case report: clinical and virological characteristics of aseptic meningitis caused by a recombinant echovirus 18 in an immunocompetent adult
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878155/
https://www.ncbi.nlm.nih.gov/pubmed/36714132
http://dx.doi.org/10.3389/fmed.2022.1094347
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