Research progress on circular RNA vaccines

Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results. This review aims to summarize key findings and...

Descripción completa

Detalles Bibliográficos
Autores principales: Bai, Yu, Liu, Dong, He, Qian, Liu, Jianyang, Mao, Qunying, Liang, Zhenglun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878156/
https://www.ncbi.nlm.nih.gov/pubmed/36713460
http://dx.doi.org/10.3389/fimmu.2022.1091797
_version_ 1784878443098275840
author Bai, Yu
Liu, Dong
He, Qian
Liu, Jianyang
Mao, Qunying
Liang, Zhenglun
author_facet Bai, Yu
Liu, Dong
He, Qian
Liu, Jianyang
Mao, Qunying
Liang, Zhenglun
author_sort Bai, Yu
collection PubMed
description Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results. This review aims to summarize key findings and important progress made in circRNA research, the in vivo metabolism and biological functions of circRNAs, and research progress and production process of circRNA vaccines. Further, considerations regarding the quality control of circRNA vaccines are highlighted herein, and the main challenges and problem-solving strategies in circRNA vaccine development and quality control are outlined to provide a reference for circRNA vaccine-related research.
format Online
Article
Text
id pubmed-9878156
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98781562023-01-27 Research progress on circular RNA vaccines Bai, Yu Liu, Dong He, Qian Liu, Jianyang Mao, Qunying Liang, Zhenglun Front Immunol Immunology Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results. This review aims to summarize key findings and important progress made in circRNA research, the in vivo metabolism and biological functions of circRNAs, and research progress and production process of circRNA vaccines. Further, considerations regarding the quality control of circRNA vaccines are highlighted herein, and the main challenges and problem-solving strategies in circRNA vaccine development and quality control are outlined to provide a reference for circRNA vaccine-related research. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9878156/ /pubmed/36713460 http://dx.doi.org/10.3389/fimmu.2022.1091797 Text en Copyright © 2023 Bai, Liu, He, Liu, Mao and Liang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Bai, Yu
Liu, Dong
He, Qian
Liu, Jianyang
Mao, Qunying
Liang, Zhenglun
Research progress on circular RNA vaccines
title Research progress on circular RNA vaccines
title_full Research progress on circular RNA vaccines
title_fullStr Research progress on circular RNA vaccines
title_full_unstemmed Research progress on circular RNA vaccines
title_short Research progress on circular RNA vaccines
title_sort research progress on circular rna vaccines
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878156/
https://www.ncbi.nlm.nih.gov/pubmed/36713460
http://dx.doi.org/10.3389/fimmu.2022.1091797
work_keys_str_mv AT baiyu researchprogressoncircularrnavaccines
AT liudong researchprogressoncircularrnavaccines
AT heqian researchprogressoncircularrnavaccines
AT liujianyang researchprogressoncircularrnavaccines
AT maoqunying researchprogressoncircularrnavaccines
AT liangzhenglun researchprogressoncircularrnavaccines

Ejemplares similares