Derivatives of 2-aminobenzimidazole potentiate ASIC open state with slow kinetics of activation and desensitization

The pharmacology of acid-sensitive ion channels (ASICs) is diverse, but potent and selective modulators, for instance for ASIC2a, are still lacking. In the present work we studied the effect of five 2-aminobenzimidazole derivatives on native ASICs in rat brain neurons and recombinant receptors expre...

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Detalles Bibliográficos
Autores principales: Evlanenkov, Konstantin K, Komarova, Margarita S, Dron, Mikhail Y, Nikolaev, Maxim V, Zhukovskaya, Olga N, Gurova, Nataliya A, Tikhonov, Denis B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878307/
https://www.ncbi.nlm.nih.gov/pubmed/36711018
http://dx.doi.org/10.3389/fphys.2023.1018551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878307/
https://www.ncbi.nlm.nih.gov/pubmed/36711018
http://dx.doi.org/10.3389/fphys.2023.1018551

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