Cargando…
Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis
Tuberculosis (TB) patients show dysregulated immunity, iron metabolism, and anemia. In this study, circulatory cytokines, trace metals, and iron-related proteins (hepcidin, ferroportin, transferrin, Dmt1, Nramp1, ferritin, ceruloplasmin, hemojuvelin, aconitase, and transferrin receptor) were monitor...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878310/ https://www.ncbi.nlm.nih.gov/pubmed/36713405 http://dx.doi.org/10.3389/fimmu.2022.985538 |
_version_ | 1784878462086938624 |
---|---|
author | Kaushik, Sandeep R. Sahu, Sukanya Guha, Hritusree Saha, Sourav Das, Ranjit Kupa, Rukuwe-u Kapfo, Wetetsho Deka, Trinayan Basumatary, Rumi Thong, Asunu Dasgupta, Arunabha Goswami, Bidhan Pandey, Amit Kumar Saikia, Lahari Khamo, Vinotsole Das, Anjan Nanda, Ranjan Kumar |
author_facet | Kaushik, Sandeep R. Sahu, Sukanya Guha, Hritusree Saha, Sourav Das, Ranjit Kupa, Rukuwe-u Kapfo, Wetetsho Deka, Trinayan Basumatary, Rumi Thong, Asunu Dasgupta, Arunabha Goswami, Bidhan Pandey, Amit Kumar Saikia, Lahari Khamo, Vinotsole Das, Anjan Nanda, Ranjan Kumar |
author_sort | Kaushik, Sandeep R. |
collection | PubMed |
description | Tuberculosis (TB) patients show dysregulated immunity, iron metabolism, and anemia. In this study, circulatory cytokines, trace metals, and iron-related proteins (hepcidin, ferroportin, transferrin, Dmt1, Nramp1, ferritin, ceruloplasmin, hemojuvelin, aconitase, and transferrin receptor) were monitored in case (active tuberculosis patients: ATB) and control (non-tuberculosis: NTB and healthy) study populations (n = 72, male: 100%, mean age, 42.94 years; range, 17–83 years). Using serum elemental and cytokine levels, a partial least square discriminate analysis model (PLS-DA) was built, which clustered ATB patients away from NTB and healthy controls. Based on the PLS-DA variable importance in projection (VIP) score and analysis of variance (ANOVA), 13 variables were selected as important biosignatures [IL-18, IL-10, IL-13, IFN-γ, TNF-α, IL-5, IL-12 (p70), IL-1β, copper, zinc, selenium, iron, and aluminum]. Interestingly, low iron and selenium levels and high copper and aluminum levels were observed in ATB subjects. Low circulatory levels of transferrin, ferroportin, and hemojuvelin with higher ferritin and ceruloplasmin levels observed in ATB subjects demonstrate an altered iron metabolism, which partially resolved upon 6 months of anti-TB therapy. The identified biosignature in TB patients demonstrated perturbed iron homeostasis with anemia of inflammation, which could be useful targets for the development of host-directed adjunct therapeutics. |
format | Online Article Text |
id | pubmed-9878310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98783102023-01-27 Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis Kaushik, Sandeep R. Sahu, Sukanya Guha, Hritusree Saha, Sourav Das, Ranjit Kupa, Rukuwe-u Kapfo, Wetetsho Deka, Trinayan Basumatary, Rumi Thong, Asunu Dasgupta, Arunabha Goswami, Bidhan Pandey, Amit Kumar Saikia, Lahari Khamo, Vinotsole Das, Anjan Nanda, Ranjan Kumar Front Immunol Immunology Tuberculosis (TB) patients show dysregulated immunity, iron metabolism, and anemia. In this study, circulatory cytokines, trace metals, and iron-related proteins (hepcidin, ferroportin, transferrin, Dmt1, Nramp1, ferritin, ceruloplasmin, hemojuvelin, aconitase, and transferrin receptor) were monitored in case (active tuberculosis patients: ATB) and control (non-tuberculosis: NTB and healthy) study populations (n = 72, male: 100%, mean age, 42.94 years; range, 17–83 years). Using serum elemental and cytokine levels, a partial least square discriminate analysis model (PLS-DA) was built, which clustered ATB patients away from NTB and healthy controls. Based on the PLS-DA variable importance in projection (VIP) score and analysis of variance (ANOVA), 13 variables were selected as important biosignatures [IL-18, IL-10, IL-13, IFN-γ, TNF-α, IL-5, IL-12 (p70), IL-1β, copper, zinc, selenium, iron, and aluminum]. Interestingly, low iron and selenium levels and high copper and aluminum levels were observed in ATB subjects. Low circulatory levels of transferrin, ferroportin, and hemojuvelin with higher ferritin and ceruloplasmin levels observed in ATB subjects demonstrate an altered iron metabolism, which partially resolved upon 6 months of anti-TB therapy. The identified biosignature in TB patients demonstrated perturbed iron homeostasis with anemia of inflammation, which could be useful targets for the development of host-directed adjunct therapeutics. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9878310/ /pubmed/36713405 http://dx.doi.org/10.3389/fimmu.2022.985538 Text en Copyright © 2023 Kaushik, Sahu, Guha, Saha, Das, Kupa, Kapfo, Deka, Basumatary, Thong, Dasgupta, Goswami, Pandey, Saikia, Khamo, Das and Nanda https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Kaushik, Sandeep R. Sahu, Sukanya Guha, Hritusree Saha, Sourav Das, Ranjit Kupa, Rukuwe-u Kapfo, Wetetsho Deka, Trinayan Basumatary, Rumi Thong, Asunu Dasgupta, Arunabha Goswami, Bidhan Pandey, Amit Kumar Saikia, Lahari Khamo, Vinotsole Das, Anjan Nanda, Ranjan Kumar Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis |
title | Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis |
title_full | Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis |
title_fullStr | Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis |
title_full_unstemmed | Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis |
title_short | Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis |
title_sort | low circulatory fe and se levels with a higher il-6/il-10 ratio provide nutritional immunity in tuberculosis |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878310/ https://www.ncbi.nlm.nih.gov/pubmed/36713405 http://dx.doi.org/10.3389/fimmu.2022.985538 |
work_keys_str_mv | AT kaushiksandeepr lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT sahusukanya lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT guhahritusree lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT sahasourav lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT dasranjit lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT kuparukuweu lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT kapfowetetsho lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT dekatrinayan lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT basumataryrumi lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT thongasunu lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT dasguptaarunabha lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT goswamibidhan lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT pandeyamitkumar lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT saikialahari lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT khamovinotsole lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT dasanjan lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis AT nandaranjankumar lowcirculatoryfeandselevelswithahigheril6il10ratioprovidenutritionalimmunityintuberculosis |