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Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis

Tuberculosis (TB) patients show dysregulated immunity, iron metabolism, and anemia. In this study, circulatory cytokines, trace metals, and iron-related proteins (hepcidin, ferroportin, transferrin, Dmt1, Nramp1, ferritin, ceruloplasmin, hemojuvelin, aconitase, and transferrin receptor) were monitor...

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Autores principales: Kaushik, Sandeep R., Sahu, Sukanya, Guha, Hritusree, Saha, Sourav, Das, Ranjit, Kupa, Rukuwe-u, Kapfo, Wetetsho, Deka, Trinayan, Basumatary, Rumi, Thong, Asunu, Dasgupta, Arunabha, Goswami, Bidhan, Pandey, Amit Kumar, Saikia, Lahari, Khamo, Vinotsole, Das, Anjan, Nanda, Ranjan Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878310/
https://www.ncbi.nlm.nih.gov/pubmed/36713405
http://dx.doi.org/10.3389/fimmu.2022.985538
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author Kaushik, Sandeep R.
Sahu, Sukanya
Guha, Hritusree
Saha, Sourav
Das, Ranjit
Kupa, Rukuwe-u
Kapfo, Wetetsho
Deka, Trinayan
Basumatary, Rumi
Thong, Asunu
Dasgupta, Arunabha
Goswami, Bidhan
Pandey, Amit Kumar
Saikia, Lahari
Khamo, Vinotsole
Das, Anjan
Nanda, Ranjan Kumar
author_facet Kaushik, Sandeep R.
Sahu, Sukanya
Guha, Hritusree
Saha, Sourav
Das, Ranjit
Kupa, Rukuwe-u
Kapfo, Wetetsho
Deka, Trinayan
Basumatary, Rumi
Thong, Asunu
Dasgupta, Arunabha
Goswami, Bidhan
Pandey, Amit Kumar
Saikia, Lahari
Khamo, Vinotsole
Das, Anjan
Nanda, Ranjan Kumar
author_sort Kaushik, Sandeep R.
collection PubMed
description Tuberculosis (TB) patients show dysregulated immunity, iron metabolism, and anemia. In this study, circulatory cytokines, trace metals, and iron-related proteins (hepcidin, ferroportin, transferrin, Dmt1, Nramp1, ferritin, ceruloplasmin, hemojuvelin, aconitase, and transferrin receptor) were monitored in case (active tuberculosis patients: ATB) and control (non-tuberculosis: NTB and healthy) study populations (n = 72, male: 100%, mean age, 42.94 years; range, 17–83 years). Using serum elemental and cytokine levels, a partial least square discriminate analysis model (PLS-DA) was built, which clustered ATB patients away from NTB and healthy controls. Based on the PLS-DA variable importance in projection (VIP) score and analysis of variance (ANOVA), 13 variables were selected as important biosignatures [IL-18, IL-10, IL-13, IFN-γ, TNF-α, IL-5, IL-12 (p70), IL-1β, copper, zinc, selenium, iron, and aluminum]. Interestingly, low iron and selenium levels and high copper and aluminum levels were observed in ATB subjects. Low circulatory levels of transferrin, ferroportin, and hemojuvelin with higher ferritin and ceruloplasmin levels observed in ATB subjects demonstrate an altered iron metabolism, which partially resolved upon 6 months of anti-TB therapy. The identified biosignature in TB patients demonstrated perturbed iron homeostasis with anemia of inflammation, which could be useful targets for the development of host-directed adjunct therapeutics.
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spelling pubmed-98783102023-01-27 Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis Kaushik, Sandeep R. Sahu, Sukanya Guha, Hritusree Saha, Sourav Das, Ranjit Kupa, Rukuwe-u Kapfo, Wetetsho Deka, Trinayan Basumatary, Rumi Thong, Asunu Dasgupta, Arunabha Goswami, Bidhan Pandey, Amit Kumar Saikia, Lahari Khamo, Vinotsole Das, Anjan Nanda, Ranjan Kumar Front Immunol Immunology Tuberculosis (TB) patients show dysregulated immunity, iron metabolism, and anemia. In this study, circulatory cytokines, trace metals, and iron-related proteins (hepcidin, ferroportin, transferrin, Dmt1, Nramp1, ferritin, ceruloplasmin, hemojuvelin, aconitase, and transferrin receptor) were monitored in case (active tuberculosis patients: ATB) and control (non-tuberculosis: NTB and healthy) study populations (n = 72, male: 100%, mean age, 42.94 years; range, 17–83 years). Using serum elemental and cytokine levels, a partial least square discriminate analysis model (PLS-DA) was built, which clustered ATB patients away from NTB and healthy controls. Based on the PLS-DA variable importance in projection (VIP) score and analysis of variance (ANOVA), 13 variables were selected as important biosignatures [IL-18, IL-10, IL-13, IFN-γ, TNF-α, IL-5, IL-12 (p70), IL-1β, copper, zinc, selenium, iron, and aluminum]. Interestingly, low iron and selenium levels and high copper and aluminum levels were observed in ATB subjects. Low circulatory levels of transferrin, ferroportin, and hemojuvelin with higher ferritin and ceruloplasmin levels observed in ATB subjects demonstrate an altered iron metabolism, which partially resolved upon 6 months of anti-TB therapy. The identified biosignature in TB patients demonstrated perturbed iron homeostasis with anemia of inflammation, which could be useful targets for the development of host-directed adjunct therapeutics. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9878310/ /pubmed/36713405 http://dx.doi.org/10.3389/fimmu.2022.985538 Text en Copyright © 2023 Kaushik, Sahu, Guha, Saha, Das, Kupa, Kapfo, Deka, Basumatary, Thong, Dasgupta, Goswami, Pandey, Saikia, Khamo, Das and Nanda https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kaushik, Sandeep R.
Sahu, Sukanya
Guha, Hritusree
Saha, Sourav
Das, Ranjit
Kupa, Rukuwe-u
Kapfo, Wetetsho
Deka, Trinayan
Basumatary, Rumi
Thong, Asunu
Dasgupta, Arunabha
Goswami, Bidhan
Pandey, Amit Kumar
Saikia, Lahari
Khamo, Vinotsole
Das, Anjan
Nanda, Ranjan Kumar
Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis
title Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis
title_full Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis
title_fullStr Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis
title_full_unstemmed Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis
title_short Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis
title_sort low circulatory fe and se levels with a higher il-6/il-10 ratio provide nutritional immunity in tuberculosis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878310/
https://www.ncbi.nlm.nih.gov/pubmed/36713405
http://dx.doi.org/10.3389/fimmu.2022.985538
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