Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity

Recent studies have shown that RNA-dependent RNA polymerase (RdRp), 3-chymotrypsin-like protease (3CLpro), and papain-like protease (PLpro) are necessary for SARS-CoV-2 replication. Among these three enzymes, PLpro exhibits both proteolytic and deubiquitinase (DUB) activity and is responsible for di...

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Detalles Bibliográficos
Autores principales: Kawall, Anasha, Lewis, Devin S. M., Sharma, Avini, Chavada, Krishna, Deshmukh, Rahul, Rayalam, Srujana, Mody, Vicky, Taval, Shashidharamurthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878345/
https://www.ncbi.nlm.nih.gov/pubmed/36712981
http://dx.doi.org/10.3389/fchem.2022.1100460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878345/
https://www.ncbi.nlm.nih.gov/pubmed/36712981
http://dx.doi.org/10.3389/fchem.2022.1100460

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