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Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort

Several risk factors have been identified for the development of gastric adenocarcinoma (GAC), where the control group was usually a healthy population. However, it is unclear at what stage known risk factor exert their influence toward the progression to cancer. Based on the Wuwei Cohort, we enroll...

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Autores principales: Chen, Zhaofeng, Zheng, Ya, Fan, Ping, Li, Min, Liu, Wei, Yuan, Hao, Liu, Xin, Zhang, Zhiyi, Wu, Zhengqi, Wang, Yuping, Ji, Rui, Guo, Qinghong, Ye, Yuwei, Zhang, Jinhua, Li, Xiaohua, An, Feng, Lu, Linzhi, Li, Youpeng, Wang, Xiang, Zhang, Jun, Guan, Quanlin, Li, Qiang, Liu, Min, Ren, Qian, Hu, Xiaobin, Lu, Hong, Zhang, Hongling, Zhao, Yue, Gou, Xi, Shu, Xiaochuang, Wang, Jun, Hu, Zenan, Xue, Siqian, Liu, Jiankang, Zhou, Yongning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878447/
https://www.ncbi.nlm.nih.gov/pubmed/36713177
http://dx.doi.org/10.3389/fmicb.2022.1024155
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author Chen, Zhaofeng
Zheng, Ya
Fan, Ping
Li, Min
Liu, Wei
Yuan, Hao
Liu, Xin
Zhang, Zhiyi
Wu, Zhengqi
Wang, Yuping
Ji, Rui
Guo, Qinghong
Ye, Yuwei
Zhang, Jinhua
Li, Xiaohua
An, Feng
Lu, Linzhi
Li, Youpeng
Wang, Xiang
Zhang, Jun
Guan, Quanlin
Li, Qiang
Liu, Min
Ren, Qian
Hu, Xiaobin
Lu, Hong
Zhang, Hongling
Zhao, Yue
Gou, Xi
Shu, Xiaochuang
Wang, Jun
Hu, Zenan
Xue, Siqian
Liu, Jiankang
Zhou, Yongning
author_facet Chen, Zhaofeng
Zheng, Ya
Fan, Ping
Li, Min
Liu, Wei
Yuan, Hao
Liu, Xin
Zhang, Zhiyi
Wu, Zhengqi
Wang, Yuping
Ji, Rui
Guo, Qinghong
Ye, Yuwei
Zhang, Jinhua
Li, Xiaohua
An, Feng
Lu, Linzhi
Li, Youpeng
Wang, Xiang
Zhang, Jun
Guan, Quanlin
Li, Qiang
Liu, Min
Ren, Qian
Hu, Xiaobin
Lu, Hong
Zhang, Hongling
Zhao, Yue
Gou, Xi
Shu, Xiaochuang
Wang, Jun
Hu, Zenan
Xue, Siqian
Liu, Jiankang
Zhou, Yongning
author_sort Chen, Zhaofeng
collection PubMed
description Several risk factors have been identified for the development of gastric adenocarcinoma (GAC), where the control group was usually a healthy population. However, it is unclear at what stage known risk factor exert their influence toward the progression to cancer. Based on the Wuwei Cohort, we enrolled 1,739 patients with chronic non-atrophic gastritis (no-CAG), 3,409 patients with chronic atrophic gastritis (CAG), 1,757 patients with intestinal metaplasia (IM), 2,239 patients with low-grade dysplasia (LGD), and 182 patients with high-grade dysplasia (HGD) or GAC to assess the risk factors between each two consecutive stages from no-CAG to GAC/HGD using adjusted logistic regression. We found that different groups of risk factors were associated with different stages. Age, occupation of farmer, low annual family income, Helicobacter pylori (H. pylori) infection, drinking, eating hot food, histories of gastritis and peptic ulcer were associated with the development of CAG. Age, illiteracy, H. pylori infection, smoking, eating hot food, eating quickly, and histories of gastritis and gallbladder diseases were associated with the progression to IM from CAG. Male, occupation of farmer and history of peptic ulcer were associated with the development of LGD from IM. Age, male and polyp history appeared to be risk factors associated with the development of GAC/HGD from LGD. In conclusion, it seems that most risk factors function more as a set of switches that initiated the GAC carcinogenesis. H. Pylori eradication and control of other risk factors should be conducted before IM to decrease the incidence of GAC.
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spelling pubmed-98784472023-01-27 Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort Chen, Zhaofeng Zheng, Ya Fan, Ping Li, Min Liu, Wei Yuan, Hao Liu, Xin Zhang, Zhiyi Wu, Zhengqi Wang, Yuping Ji, Rui Guo, Qinghong Ye, Yuwei Zhang, Jinhua Li, Xiaohua An, Feng Lu, Linzhi Li, Youpeng Wang, Xiang Zhang, Jun Guan, Quanlin Li, Qiang Liu, Min Ren, Qian Hu, Xiaobin Lu, Hong Zhang, Hongling Zhao, Yue Gou, Xi Shu, Xiaochuang Wang, Jun Hu, Zenan Xue, Siqian Liu, Jiankang Zhou, Yongning Front Microbiol Microbiology Several risk factors have been identified for the development of gastric adenocarcinoma (GAC), where the control group was usually a healthy population. However, it is unclear at what stage known risk factor exert their influence toward the progression to cancer. Based on the Wuwei Cohort, we enrolled 1,739 patients with chronic non-atrophic gastritis (no-CAG), 3,409 patients with chronic atrophic gastritis (CAG), 1,757 patients with intestinal metaplasia (IM), 2,239 patients with low-grade dysplasia (LGD), and 182 patients with high-grade dysplasia (HGD) or GAC to assess the risk factors between each two consecutive stages from no-CAG to GAC/HGD using adjusted logistic regression. We found that different groups of risk factors were associated with different stages. Age, occupation of farmer, low annual family income, Helicobacter pylori (H. pylori) infection, drinking, eating hot food, histories of gastritis and peptic ulcer were associated with the development of CAG. Age, illiteracy, H. pylori infection, smoking, eating hot food, eating quickly, and histories of gastritis and gallbladder diseases were associated with the progression to IM from CAG. Male, occupation of farmer and history of peptic ulcer were associated with the development of LGD from IM. Age, male and polyp history appeared to be risk factors associated with the development of GAC/HGD from LGD. In conclusion, it seems that most risk factors function more as a set of switches that initiated the GAC carcinogenesis. H. Pylori eradication and control of other risk factors should be conducted before IM to decrease the incidence of GAC. Frontiers Media S.A. 2023-01-12 /pmc/articles/PMC9878447/ /pubmed/36713177 http://dx.doi.org/10.3389/fmicb.2022.1024155 Text en Copyright © 2023 Chen, Zheng, Fan, Li, Liu, Yuan, Liu, Zhang, Wu, Wang, Ji, Guo, Ye, Zhang, Li, An, Lu, Li, Wang, Zhang, Guan, Li, Liu, Ren, Hu, Lu, Zhang, Zhao, Gou, Shu, Wang, Hu, Xue, Liu and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Chen, Zhaofeng
Zheng, Ya
Fan, Ping
Li, Min
Liu, Wei
Yuan, Hao
Liu, Xin
Zhang, Zhiyi
Wu, Zhengqi
Wang, Yuping
Ji, Rui
Guo, Qinghong
Ye, Yuwei
Zhang, Jinhua
Li, Xiaohua
An, Feng
Lu, Linzhi
Li, Youpeng
Wang, Xiang
Zhang, Jun
Guan, Quanlin
Li, Qiang
Liu, Min
Ren, Qian
Hu, Xiaobin
Lu, Hong
Zhang, Hongling
Zhao, Yue
Gou, Xi
Shu, Xiaochuang
Wang, Jun
Hu, Zenan
Xue, Siqian
Liu, Jiankang
Zhou, Yongning
Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort
title Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort
title_full Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort
title_fullStr Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort
title_full_unstemmed Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort
title_short Risk factors in the development of gastric adenocarcinoma in the general population: A cross-sectional study of the Wuwei Cohort
title_sort risk factors in the development of gastric adenocarcinoma in the general population: a cross-sectional study of the wuwei cohort
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878447/
https://www.ncbi.nlm.nih.gov/pubmed/36713177
http://dx.doi.org/10.3389/fmicb.2022.1024155
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