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Strategies to Prevent Transmission of Candida auris in Healthcare Settings

PURPOSE OF REVIEW: Candida auris, a recently recognized yeast pathogen, has become a major public health threat due to the problems associated with its accurate identification, intrinsic and acquired resistance to antifungal drugs, and its potential to easily contaminate the environment causing clon...

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Autores principales: Ahmad, Suhail, Asadzadeh, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878498/
https://www.ncbi.nlm.nih.gov/pubmed/36718372
http://dx.doi.org/10.1007/s12281-023-00451-7
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author Ahmad, Suhail
Asadzadeh, Mohammad
author_facet Ahmad, Suhail
Asadzadeh, Mohammad
author_sort Ahmad, Suhail
collection PubMed
description PURPOSE OF REVIEW: Candida auris, a recently recognized yeast pathogen, has become a major public health threat due to the problems associated with its accurate identification, intrinsic and acquired resistance to antifungal drugs, and its potential to easily contaminate the environment causing clonal outbreaks in healthcare facilities. These outbreaks are associated with high mortality rates particularly among older patients with multiple comorbidities under intensive care settings. The purpose of this review is to highlight strategies that are being adapted to prevent transmission of C. auris in healthcare settings. RECENT FINDINGS: Colonized patients shed C. auris into their environment which contaminates surrounding equipment. It resists elimination even by robust decontamination procedures and is easily transmitted to new patients during close contact resulting in outbreaks. Efforts are being made to rapidly identify C. auris-infected/C. auris-colonized patients, to determine its susceptibility to antifungals, and to perform effective cleaning and decontamination of the environment and isolation of colonized patients to prevent further transmission. SUMMARY: Rapid and accurate identification of hospitalized patients infected/colonized with C. auris, rapid detection of its susceptibility patterns, and appropriate use of infection control measures can help to contain the spread of this highly pathogenic yeast in healthcare settings and prevent/control outbreaks.
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spelling pubmed-98784982023-01-26 Strategies to Prevent Transmission of Candida auris in Healthcare Settings Ahmad, Suhail Asadzadeh, Mohammad Curr Fungal Infect Rep Article PURPOSE OF REVIEW: Candida auris, a recently recognized yeast pathogen, has become a major public health threat due to the problems associated with its accurate identification, intrinsic and acquired resistance to antifungal drugs, and its potential to easily contaminate the environment causing clonal outbreaks in healthcare facilities. These outbreaks are associated with high mortality rates particularly among older patients with multiple comorbidities under intensive care settings. The purpose of this review is to highlight strategies that are being adapted to prevent transmission of C. auris in healthcare settings. RECENT FINDINGS: Colonized patients shed C. auris into their environment which contaminates surrounding equipment. It resists elimination even by robust decontamination procedures and is easily transmitted to new patients during close contact resulting in outbreaks. Efforts are being made to rapidly identify C. auris-infected/C. auris-colonized patients, to determine its susceptibility to antifungals, and to perform effective cleaning and decontamination of the environment and isolation of colonized patients to prevent further transmission. SUMMARY: Rapid and accurate identification of hospitalized patients infected/colonized with C. auris, rapid detection of its susceptibility patterns, and appropriate use of infection control measures can help to contain the spread of this highly pathogenic yeast in healthcare settings and prevent/control outbreaks. Springer US 2023-01-26 2023 /pmc/articles/PMC9878498/ /pubmed/36718372 http://dx.doi.org/10.1007/s12281-023-00451-7 Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Ahmad, Suhail
Asadzadeh, Mohammad
Strategies to Prevent Transmission of Candida auris in Healthcare Settings
title Strategies to Prevent Transmission of Candida auris in Healthcare Settings
title_full Strategies to Prevent Transmission of Candida auris in Healthcare Settings
title_fullStr Strategies to Prevent Transmission of Candida auris in Healthcare Settings
title_full_unstemmed Strategies to Prevent Transmission of Candida auris in Healthcare Settings
title_short Strategies to Prevent Transmission of Candida auris in Healthcare Settings
title_sort strategies to prevent transmission of candida auris in healthcare settings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878498/
https://www.ncbi.nlm.nih.gov/pubmed/36718372
http://dx.doi.org/10.1007/s12281-023-00451-7
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