Copper-Plumbagin Complex Produces Potent Anticancer Effects by Depolymerizing Microtubules and Inducing Reactive Oxygen Species and DNA Damage

[Image: see text] Here, we have synthesized a copper complex of plumbagin (Cu-PLN) and investigated its antiproliferative activities in different cancer cells. The crystal structure of Cu-PLN showed that the complex was square planar with a binding stoichiometry of 1:2 (Cu/Plumbagin). Cu-PLN inhibit...

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Detalles Bibliográficos
Autores principales: Mukherjee, Sandipan, Sawant, Avishkar V., Prassanawar, Shweta S., Panda, Dulal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878539/
https://www.ncbi.nlm.nih.gov/pubmed/36713695
http://dx.doi.org/10.1021/acsomega.2c06691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878539/
https://www.ncbi.nlm.nih.gov/pubmed/36713695
http://dx.doi.org/10.1021/acsomega.2c06691

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