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Functional Impact of a Cancer-Related Variant in Human Δ(1)-Pyrroline-5-Carboxylate Reductase 1

[Image: see text] Pyrroline-5-carboxylate reductase (PYCR) is a proline biosynthetic enzyme that catalyzes the NAD(P)H-dependent reduction of Δ(1)-pyrroline-5-carboxylate (P5C) to proline. Humans have three PYCR isoforms, with PYCR1 often upregulated in different types of cancers. Here, we studied t...

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Detalles Bibliográficos
Autores principales:	Daudu, Oseeyi I., Meeks, Kaylen R., Zhang, Lu, Seravalli, Javier, Tanner, John J., Becker, Donald F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878632/ https://www.ncbi.nlm.nih.gov/pubmed/36713721 http://dx.doi.org/10.1021/acsomega.2c07788

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