Cargando…

A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks

In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory networks so that the expression of core genes (partial system) is insensitive to environmental changes. Then, we found the...

Descripción completa

Detalles Bibliográficos
Autores principales: Hatakeyama, Tetsuhiro S., Kaneko, Kunihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879506/
https://www.ncbi.nlm.nih.gov/pubmed/36701362
http://dx.doi.org/10.1371/journal.pone.0277181
_version_ 1784878705543217152
author Hatakeyama, Tetsuhiro S.
Kaneko, Kunihiko
author_facet Hatakeyama, Tetsuhiro S.
Kaneko, Kunihiko
author_sort Hatakeyama, Tetsuhiro S.
collection PubMed
description In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory networks so that the expression of core genes (partial system) is insensitive to environmental changes. Then, we found the expression levels of the remaining genes autonomously increase to provide a plastic (sensitive) response. A feedforward structure from the non-core to core genes evolved autonomously. Negative proportionality was observed between the average changes in core and non-core genes, reflecting reciprocity between the macroscopic robustness of homeostatic genes and plasticity of regulator genes. The proportion coefficient between those genes is represented by their number ratio, as in the “lever principle”, whereas the decrease in the ratio results in a transition from perfect to partial adaptation, in which only a portion of the core genes exhibits robustness against environmental changes. This reciprocity between robustness and plasticity was satisfied throughout the evolutionary course, imposing an evolutionary constraint. This result suggests a simple macroscopic law for the adaptation characteristic in evolved complex biological networks.
format Online
Article
Text
id pubmed-9879506
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-98795062023-01-27 A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks Hatakeyama, Tetsuhiro S. Kaneko, Kunihiko PLoS One Research Article In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory networks so that the expression of core genes (partial system) is insensitive to environmental changes. Then, we found the expression levels of the remaining genes autonomously increase to provide a plastic (sensitive) response. A feedforward structure from the non-core to core genes evolved autonomously. Negative proportionality was observed between the average changes in core and non-core genes, reflecting reciprocity between the macroscopic robustness of homeostatic genes and plasticity of regulator genes. The proportion coefficient between those genes is represented by their number ratio, as in the “lever principle”, whereas the decrease in the ratio results in a transition from perfect to partial adaptation, in which only a portion of the core genes exhibits robustness against environmental changes. This reciprocity between robustness and plasticity was satisfied throughout the evolutionary course, imposing an evolutionary constraint. This result suggests a simple macroscopic law for the adaptation characteristic in evolved complex biological networks. Public Library of Science 2023-01-26 /pmc/articles/PMC9879506/ /pubmed/36701362 http://dx.doi.org/10.1371/journal.pone.0277181 Text en © 2023 Hatakeyama, Kaneko https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hatakeyama, Tetsuhiro S.
Kaneko, Kunihiko
A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks
title A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks
title_full A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks
title_fullStr A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks
title_full_unstemmed A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks
title_short A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks
title_sort linear reciprocal relationship between robustness and plasticity in homeostatic biological networks
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879506/
https://www.ncbi.nlm.nih.gov/pubmed/36701362
http://dx.doi.org/10.1371/journal.pone.0277181
work_keys_str_mv AT hatakeyamatetsuhiros alinearreciprocalrelationshipbetweenrobustnessandplasticityinhomeostaticbiologicalnetworks
AT kanekokunihiko alinearreciprocalrelationshipbetweenrobustnessandplasticityinhomeostaticbiologicalnetworks
AT hatakeyamatetsuhiros linearreciprocalrelationshipbetweenrobustnessandplasticityinhomeostaticbiologicalnetworks
AT kanekokunihiko linearreciprocalrelationshipbetweenrobustnessandplasticityinhomeostaticbiologicalnetworks