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A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks
In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory networks so that the expression of core genes (partial system) is insensitive to environmental changes. Then, we found the...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879506/ https://www.ncbi.nlm.nih.gov/pubmed/36701362 http://dx.doi.org/10.1371/journal.pone.0277181 |
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author | Hatakeyama, Tetsuhiro S. Kaneko, Kunihiko |
author_facet | Hatakeyama, Tetsuhiro S. Kaneko, Kunihiko |
author_sort | Hatakeyama, Tetsuhiro S. |
collection | PubMed |
description | In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory networks so that the expression of core genes (partial system) is insensitive to environmental changes. Then, we found the expression levels of the remaining genes autonomously increase to provide a plastic (sensitive) response. A feedforward structure from the non-core to core genes evolved autonomously. Negative proportionality was observed between the average changes in core and non-core genes, reflecting reciprocity between the macroscopic robustness of homeostatic genes and plasticity of regulator genes. The proportion coefficient between those genes is represented by their number ratio, as in the “lever principle”, whereas the decrease in the ratio results in a transition from perfect to partial adaptation, in which only a portion of the core genes exhibits robustness against environmental changes. This reciprocity between robustness and plasticity was satisfied throughout the evolutionary course, imposing an evolutionary constraint. This result suggests a simple macroscopic law for the adaptation characteristic in evolved complex biological networks. |
format | Online Article Text |
id | pubmed-9879506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-98795062023-01-27 A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks Hatakeyama, Tetsuhiro S. Kaneko, Kunihiko PLoS One Research Article In physics of living systems, a search for relationships of a few macroscopic variables that emerge from many microscopic elements is a central issue. We evolved gene regulatory networks so that the expression of core genes (partial system) is insensitive to environmental changes. Then, we found the expression levels of the remaining genes autonomously increase to provide a plastic (sensitive) response. A feedforward structure from the non-core to core genes evolved autonomously. Negative proportionality was observed between the average changes in core and non-core genes, reflecting reciprocity between the macroscopic robustness of homeostatic genes and plasticity of regulator genes. The proportion coefficient between those genes is represented by their number ratio, as in the “lever principle”, whereas the decrease in the ratio results in a transition from perfect to partial adaptation, in which only a portion of the core genes exhibits robustness against environmental changes. This reciprocity between robustness and plasticity was satisfied throughout the evolutionary course, imposing an evolutionary constraint. This result suggests a simple macroscopic law for the adaptation characteristic in evolved complex biological networks. Public Library of Science 2023-01-26 /pmc/articles/PMC9879506/ /pubmed/36701362 http://dx.doi.org/10.1371/journal.pone.0277181 Text en © 2023 Hatakeyama, Kaneko https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hatakeyama, Tetsuhiro S. Kaneko, Kunihiko A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks |
title | A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks |
title_full | A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks |
title_fullStr | A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks |
title_full_unstemmed | A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks |
title_short | A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks |
title_sort | linear reciprocal relationship between robustness and plasticity in homeostatic biological networks |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879506/ https://www.ncbi.nlm.nih.gov/pubmed/36701362 http://dx.doi.org/10.1371/journal.pone.0277181 |
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