Age-related changes in tau and autophagy in human brain in the absence of neurodegeneration

Tau becomes abnormally hyper-phosphorylated and aggregated in tauopathies like Alzheimers disease (AD). As age is the greatest risk factor for developing AD, it is important to understand how tau protein itself, and the pathways implicated in its turnover, change during aging. We investigated age-re...

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Detalles Bibliográficos
Autores principales: Chatterjee, Shreyasi, Sealey, Megan, Ruiz, Eva, Pegasiou, Chrysia M., Brookes, Keeley, Green, Sam, Crisford, Anna, Duque-Vasquez, Michael, Luckett, Emma, Robertson, Rebecca, Richardson, Philippa, Vajramani, Girish, Grundy, Paul, Bulters, Diederik, Proud, Christopher, Vargas-Caballero, Mariana, Mudher, Amritpal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879510/
https://www.ncbi.nlm.nih.gov/pubmed/36701399
http://dx.doi.org/10.1371/journal.pone.0262792

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