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The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori

Stomach cancer is a leading cause of cancer death. Helicobacter pylori is a bacterial gastric pathogen that is the primary risk factor for carcinogenesis, associated with its induction of inflammation and DNA damage. Dicarbonyl electrophiles are generated from lipid peroxidation during the inflammat...

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Autores principales: Gobert, Alain P., Asim, Mohammad, Smith, Thaddeus M., Williams, Kamery J., Barry, Daniel P., Allaman, Margaret M., McNamara, Kara M., Hawkins, Caroline V., Delgado, Alberto G., Piazuelo, M. Blanca, Rathmacher, John A., Wilson, Keith T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879697/
https://www.ncbi.nlm.nih.gov/pubmed/36493697
http://dx.doi.org/10.1016/j.biopha.2022.114092
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author Gobert, Alain P.
Asim, Mohammad
Smith, Thaddeus M.
Williams, Kamery J.
Barry, Daniel P.
Allaman, Margaret M.
McNamara, Kara M.
Hawkins, Caroline V.
Delgado, Alberto G.
Piazuelo, M. Blanca
Rathmacher, John A.
Wilson, Keith T.
author_facet Gobert, Alain P.
Asim, Mohammad
Smith, Thaddeus M.
Williams, Kamery J.
Barry, Daniel P.
Allaman, Margaret M.
McNamara, Kara M.
Hawkins, Caroline V.
Delgado, Alberto G.
Piazuelo, M. Blanca
Rathmacher, John A.
Wilson, Keith T.
author_sort Gobert, Alain P.
collection PubMed
description Stomach cancer is a leading cause of cancer death. Helicobacter pylori is a bacterial gastric pathogen that is the primary risk factor for carcinogenesis, associated with its induction of inflammation and DNA damage. Dicarbonyl electrophiles are generated from lipid peroxidation during the inflammatory response and form covalent adducts with amine-containing macromolecules. 2-hydroxybenzylamine (2-HOBA) is a natural compound derived from buckwheat seeds and acts as a potent scavenger of reactive aldehydes. Our goal was to investigate the effect of 2-HOBA on the pathogenesis of H. pylori infection. We used transgenic FVB/N insulin-gastrin (INS-GAS) mice as a model of gastric cancer. First, we found that 2-HOBA is bioavailable in the gastric tissues of these mice after supplementation in the drinking water. Moreover, 2-HOBA reduced the development of gastritis in H. pylori-infected INS-GAS mice without affecting the bacterial colonization level in the stomach. Further, we show that the development of gastric dysplasia and carcinoma was significantly reduced by 2-HOBA. Concomitantly, DNA damage were also inhibited by 2-HOBA treatment in H. pylori-infected mice. In parallel, DNA damage was inhibited by 2-HOBA in H. pylori-infected gastric epithelial cells in vitro. In conclusion, 2-HOBA, which has been shown to be safe in human clinical trials, represents a promising nutritional compound for the chemoprevention of the more severe effects of H. pylori infection.
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spelling pubmed-98796972023-02-01 The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori Gobert, Alain P. Asim, Mohammad Smith, Thaddeus M. Williams, Kamery J. Barry, Daniel P. Allaman, Margaret M. McNamara, Kara M. Hawkins, Caroline V. Delgado, Alberto G. Piazuelo, M. Blanca Rathmacher, John A. Wilson, Keith T. Biomed Pharmacother Article Stomach cancer is a leading cause of cancer death. Helicobacter pylori is a bacterial gastric pathogen that is the primary risk factor for carcinogenesis, associated with its induction of inflammation and DNA damage. Dicarbonyl electrophiles are generated from lipid peroxidation during the inflammatory response and form covalent adducts with amine-containing macromolecules. 2-hydroxybenzylamine (2-HOBA) is a natural compound derived from buckwheat seeds and acts as a potent scavenger of reactive aldehydes. Our goal was to investigate the effect of 2-HOBA on the pathogenesis of H. pylori infection. We used transgenic FVB/N insulin-gastrin (INS-GAS) mice as a model of gastric cancer. First, we found that 2-HOBA is bioavailable in the gastric tissues of these mice after supplementation in the drinking water. Moreover, 2-HOBA reduced the development of gastritis in H. pylori-infected INS-GAS mice without affecting the bacterial colonization level in the stomach. Further, we show that the development of gastric dysplasia and carcinoma was significantly reduced by 2-HOBA. Concomitantly, DNA damage were also inhibited by 2-HOBA treatment in H. pylori-infected mice. In parallel, DNA damage was inhibited by 2-HOBA in H. pylori-infected gastric epithelial cells in vitro. In conclusion, 2-HOBA, which has been shown to be safe in human clinical trials, represents a promising nutritional compound for the chemoprevention of the more severe effects of H. pylori infection. 2023-02 2022-12-06 /pmc/articles/PMC9879697/ /pubmed/36493697 http://dx.doi.org/10.1016/j.biopha.2022.114092 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.Org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Article
Gobert, Alain P.
Asim, Mohammad
Smith, Thaddeus M.
Williams, Kamery J.
Barry, Daniel P.
Allaman, Margaret M.
McNamara, Kara M.
Hawkins, Caroline V.
Delgado, Alberto G.
Piazuelo, M. Blanca
Rathmacher, John A.
Wilson, Keith T.
The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori
title The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori
title_full The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori
title_fullStr The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori
title_full_unstemmed The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori
title_short The nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-HOBA) attenuates gastric cancer development caused by Helicobacter pylori
title_sort nutraceutical electrophile scavenger 2-hydroxybenzylamine (2-hoba) attenuates gastric cancer development caused by helicobacter pylori
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879697/
https://www.ncbi.nlm.nih.gov/pubmed/36493697
http://dx.doi.org/10.1016/j.biopha.2022.114092
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