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Exploiting a conjugative endogenous CRISPR-Cas3 system to tackle multidrug-resistant Klebsiella pneumoniae

BACKGROUND: Mobile plasmids play a key role in spurring the global dissemination of multidrug-resistant (MDR) K. pneumoniae, while plasmid curing has been recognized as a promising strategy to combat antimicrobial resistance. Here we exploited a K. pneumoniae native CRISPR system to cure the high-ri...

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Detalles Bibliográficos
Autores principales:	Zhou, Ying, Yang, Yang, Li, Xiaobin, Tian, Dongxing, Ai, Wenxiu, Wang, Weiwen, Wang, Bingjie, Kreiswirth, Barry N., Yu, Fangyou, Chen, Liang, Jiang, Xiaofei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879765/ https://www.ncbi.nlm.nih.gov/pubmed/36696817 http://dx.doi.org/10.1016/j.ebiom.2023.104445

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