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Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB
OBJECTIVE: Tuberculosis (TB) remains a public health concern worldwide, affecting millions of people every year. Detailed characterization of disease pathophysiology is key to proper diagnosis, disease progression, or treatment follow-up and evaluation. The present study investigated C-reactive prot...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879784/ https://www.ncbi.nlm.nih.gov/pubmed/36714271 http://dx.doi.org/10.1016/j.jctube.2023.100348 |
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author | Leboueny, Marielle Maloupazoa Siawaya, Anicet Christel Bouanga, Loraine Daisy Josiane Mvoundza Ndjindji, Ofilia Mveang Nzoghe, Amandine Djoba Siawaya, Joel Fleury |
author_facet | Leboueny, Marielle Maloupazoa Siawaya, Anicet Christel Bouanga, Loraine Daisy Josiane Mvoundza Ndjindji, Ofilia Mveang Nzoghe, Amandine Djoba Siawaya, Joel Fleury |
author_sort | Leboueny, Marielle |
collection | PubMed |
description | OBJECTIVE: Tuberculosis (TB) remains a public health concern worldwide, affecting millions of people every year. Detailed characterization of disease pathophysiology is key to proper diagnosis, disease progression, or treatment follow-up and evaluation. The present study investigated C-reactive protein and Procalcitonin (PCT) as candidate markers of early treatment response and disease activity. METHODS: From September to December 2019, 21 HIV-negative consecutive TB patients were recruited, within the setting of the Gabonese TB specialized hospital and the National Laboratory of Public Health, in a prospective study. CRP and PCT levels were measured by chemiluminescence at diagnosis and 4 weeks following the initiation of anti-TB treatment. RESULTS: The mean concentration of CRP in TB patients was 114.7 mg/L (95 % CI: [83.8–145.6]) at diagnosis and 20.2 mg/L (95 % CI: [14.1–26.4]) 4 weeks following anti-TB treatment. The drop in CRP concentrations between diagnosis, and week 4 following anti-TB treatment showed was significant (p < 0.0001). The average concentration of PCT at the time of diagnosis was 0.3 ng/mL (95 % CI: [0.19–0.41]). PCT Concentration dropped below 0.05 ng/mL 4 weeks following the start of anti-TB treatment (p < 0.01). CONCLUSION: CRP and PCT are potential TB biomarkers, each, carrying important keys. If the drop in both proteins may indicate a significant reduction of the Mtb burden, the maintenance of CRP above the inflammation threshold could indicate the presence of residual bacilli. However, the clinical translation of the present finding will require more investigation. |
format | Online Article Text |
id | pubmed-9879784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-98797842023-01-28 Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB Leboueny, Marielle Maloupazoa Siawaya, Anicet Christel Bouanga, Loraine Daisy Josiane Mvoundza Ndjindji, Ofilia Mveang Nzoghe, Amandine Djoba Siawaya, Joel Fleury J Clin Tuberc Other Mycobact Dis Article OBJECTIVE: Tuberculosis (TB) remains a public health concern worldwide, affecting millions of people every year. Detailed characterization of disease pathophysiology is key to proper diagnosis, disease progression, or treatment follow-up and evaluation. The present study investigated C-reactive protein and Procalcitonin (PCT) as candidate markers of early treatment response and disease activity. METHODS: From September to December 2019, 21 HIV-negative consecutive TB patients were recruited, within the setting of the Gabonese TB specialized hospital and the National Laboratory of Public Health, in a prospective study. CRP and PCT levels were measured by chemiluminescence at diagnosis and 4 weeks following the initiation of anti-TB treatment. RESULTS: The mean concentration of CRP in TB patients was 114.7 mg/L (95 % CI: [83.8–145.6]) at diagnosis and 20.2 mg/L (95 % CI: [14.1–26.4]) 4 weeks following anti-TB treatment. The drop in CRP concentrations between diagnosis, and week 4 following anti-TB treatment showed was significant (p < 0.0001). The average concentration of PCT at the time of diagnosis was 0.3 ng/mL (95 % CI: [0.19–0.41]). PCT Concentration dropped below 0.05 ng/mL 4 weeks following the start of anti-TB treatment (p < 0.01). CONCLUSION: CRP and PCT are potential TB biomarkers, each, carrying important keys. If the drop in both proteins may indicate a significant reduction of the Mtb burden, the maintenance of CRP above the inflammation threshold could indicate the presence of residual bacilli. However, the clinical translation of the present finding will require more investigation. Elsevier 2023-01-18 /pmc/articles/PMC9879784/ /pubmed/36714271 http://dx.doi.org/10.1016/j.jctube.2023.100348 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Leboueny, Marielle Maloupazoa Siawaya, Anicet Christel Bouanga, Loraine Daisy Josiane Mvoundza Ndjindji, Ofilia Mveang Nzoghe, Amandine Djoba Siawaya, Joel Fleury Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB |
title | Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB |
title_full | Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB |
title_fullStr | Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB |
title_full_unstemmed | Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB |
title_short | Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB |
title_sort | changes of c-reactive protein and procalcitonin after four weeks of treatment in patients with pulmonary tb |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879784/ https://www.ncbi.nlm.nih.gov/pubmed/36714271 http://dx.doi.org/10.1016/j.jctube.2023.100348 |
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