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Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB

OBJECTIVE: Tuberculosis (TB) remains a public health concern worldwide, affecting millions of people every year. Detailed characterization of disease pathophysiology is key to proper diagnosis, disease progression, or treatment follow-up and evaluation. The present study investigated C-reactive prot...

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Autores principales: Leboueny, Marielle, Maloupazoa Siawaya, Anicet Christel, Bouanga, Loraine Daisy Josiane, Mvoundza Ndjindji, Ofilia, Mveang Nzoghe, Amandine, Djoba Siawaya, Joel Fleury
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879784/
https://www.ncbi.nlm.nih.gov/pubmed/36714271
http://dx.doi.org/10.1016/j.jctube.2023.100348
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author Leboueny, Marielle
Maloupazoa Siawaya, Anicet Christel
Bouanga, Loraine Daisy Josiane
Mvoundza Ndjindji, Ofilia
Mveang Nzoghe, Amandine
Djoba Siawaya, Joel Fleury
author_facet Leboueny, Marielle
Maloupazoa Siawaya, Anicet Christel
Bouanga, Loraine Daisy Josiane
Mvoundza Ndjindji, Ofilia
Mveang Nzoghe, Amandine
Djoba Siawaya, Joel Fleury
author_sort Leboueny, Marielle
collection PubMed
description OBJECTIVE: Tuberculosis (TB) remains a public health concern worldwide, affecting millions of people every year. Detailed characterization of disease pathophysiology is key to proper diagnosis, disease progression, or treatment follow-up and evaluation. The present study investigated C-reactive protein and Procalcitonin (PCT) as candidate markers of early treatment response and disease activity. METHODS: From September to December 2019, 21 HIV-negative consecutive TB patients were recruited, within the setting of the Gabonese TB specialized hospital and the National Laboratory of Public Health, in a prospective study. CRP and PCT levels were measured by chemiluminescence at diagnosis and 4 weeks following the initiation of anti-TB treatment. RESULTS: The mean concentration of CRP in TB patients was 114.7 mg/L (95 % CI: [83.8–145.6]) at diagnosis and 20.2 mg/L (95 % CI: [14.1–26.4]) 4 weeks following anti-TB treatment. The drop in CRP concentrations between diagnosis, and week 4 following anti-TB treatment showed was significant (p < 0.0001). The average concentration of PCT at the time of diagnosis was 0.3 ng/mL (95 % CI: [0.19–0.41]). PCT Concentration dropped below 0.05 ng/mL 4 weeks following the start of anti-TB treatment (p < 0.01). CONCLUSION: CRP and PCT are potential TB biomarkers, each, carrying important keys. If the drop in both proteins may indicate a significant reduction of the Mtb burden, the maintenance of CRP above the inflammation threshold could indicate the presence of residual bacilli. However, the clinical translation of the present finding will require more investigation.
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spelling pubmed-98797842023-01-28 Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB Leboueny, Marielle Maloupazoa Siawaya, Anicet Christel Bouanga, Loraine Daisy Josiane Mvoundza Ndjindji, Ofilia Mveang Nzoghe, Amandine Djoba Siawaya, Joel Fleury J Clin Tuberc Other Mycobact Dis Article OBJECTIVE: Tuberculosis (TB) remains a public health concern worldwide, affecting millions of people every year. Detailed characterization of disease pathophysiology is key to proper diagnosis, disease progression, or treatment follow-up and evaluation. The present study investigated C-reactive protein and Procalcitonin (PCT) as candidate markers of early treatment response and disease activity. METHODS: From September to December 2019, 21 HIV-negative consecutive TB patients were recruited, within the setting of the Gabonese TB specialized hospital and the National Laboratory of Public Health, in a prospective study. CRP and PCT levels were measured by chemiluminescence at diagnosis and 4 weeks following the initiation of anti-TB treatment. RESULTS: The mean concentration of CRP in TB patients was 114.7 mg/L (95 % CI: [83.8–145.6]) at diagnosis and 20.2 mg/L (95 % CI: [14.1–26.4]) 4 weeks following anti-TB treatment. The drop in CRP concentrations between diagnosis, and week 4 following anti-TB treatment showed was significant (p < 0.0001). The average concentration of PCT at the time of diagnosis was 0.3 ng/mL (95 % CI: [0.19–0.41]). PCT Concentration dropped below 0.05 ng/mL 4 weeks following the start of anti-TB treatment (p < 0.01). CONCLUSION: CRP and PCT are potential TB biomarkers, each, carrying important keys. If the drop in both proteins may indicate a significant reduction of the Mtb burden, the maintenance of CRP above the inflammation threshold could indicate the presence of residual bacilli. However, the clinical translation of the present finding will require more investigation. Elsevier 2023-01-18 /pmc/articles/PMC9879784/ /pubmed/36714271 http://dx.doi.org/10.1016/j.jctube.2023.100348 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leboueny, Marielle
Maloupazoa Siawaya, Anicet Christel
Bouanga, Loraine Daisy Josiane
Mvoundza Ndjindji, Ofilia
Mveang Nzoghe, Amandine
Djoba Siawaya, Joel Fleury
Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB
title Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB
title_full Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB
title_fullStr Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB
title_full_unstemmed Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB
title_short Changes of C-reactive protein and Procalcitonin after four weeks of treatment in patients with pulmonary TB
title_sort changes of c-reactive protein and procalcitonin after four weeks of treatment in patients with pulmonary tb
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879784/
https://www.ncbi.nlm.nih.gov/pubmed/36714271
http://dx.doi.org/10.1016/j.jctube.2023.100348
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