The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male mice

BACKGROUND: The brain-derived neurotrophic factor (BDNF) Valine 66 to Methionine human polymorphism results in impaired activity-dependent BDNF release and has been linked to psychiatric disorders including depression and anxiety. We previously showed that male knock-in mice carrying the mouse Methi...

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Detalles Bibliográficos
Autores principales: Moffat, Jeffrey J., Sakhai, Samuel A., Hoisington, Zachary W., Ehinger, Yann, Ron, Dorit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879818/
https://www.ncbi.nlm.nih.gov/pubmed/36622381
http://dx.doi.org/10.1007/s00213-022-06305-3

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