USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy

The spindle assembly checkpoint (SAC) is an essential mechanism that ensures the accurate chromosome segregation during mitosis, thus preventing genomic instability. Deubiquitinases have emerged as key regulators of the SAC, mainly by determining the fate of proteins during cell cycle progression. H...

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Detalles Bibliográficos
Autores principales: Campos-Iglesias, Diana, Fraile, Julia M., Bretones, Gabriel, Montero, Alejandro A., Bonzon-Kulichenko, Elena, Vázquez, Jesús, López-Otín, Carlos, Freije, José M. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879932/
https://www.ncbi.nlm.nih.gov/pubmed/36702832
http://dx.doi.org/10.1038/s41419-023-05600-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879932/
https://www.ncbi.nlm.nih.gov/pubmed/36702832
http://dx.doi.org/10.1038/s41419-023-05600-x

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