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Design and characterization of a protein fold switching network

To better understand how amino acid sequence encodes protein structure, we engineered mutational pathways that connect three common folds (3α, β−grasp, and α/β−plait). The structures of proteins at high sequence-identity intersections in the pathways (nodes) were determined using NMR spectroscopy an...

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Detalles Bibliográficos
Autores principales:	Ruan, Biao, He, Yanan, Chen, Yingwei, Choi, Eun Jung, Chen, Yihong, Motabar, Dana, Solomon, Tsega, Simmerman, Richard, Kauffman, Thomas, Gallagher, D. Travis, Orban, John, Bryan, Philip N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879998/ https://www.ncbi.nlm.nih.gov/pubmed/36702827 http://dx.doi.org/10.1038/s41467-023-36065-3

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