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Pigs with an INS point mutation derived from zygotes electroporated with CRISPR/Cas9 and ssODN
Just one amino acid at the carboxy-terminus of the B chain distinguishes human insulin from porcine insulin. By introducing a precise point mutation into the porcine insulin (INS) gene, we were able to generate genetically modified pigs that secreted human insulin; these pigs may be suitable donors...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880039/ https://www.ncbi.nlm.nih.gov/pubmed/36711037 http://dx.doi.org/10.3389/fcell.2023.884340 |