Cucurbit[n]uril-based fluorescent indicator-displacement assays for sensing organic compounds

The widespread conversion of synthetic receptors into luminescent sensors has been achieved via the use of fluorescent-indicator displacement assays (F-IDAs). Due to their rigid structures and efficient binding affinities, cucurbit[n]urils, combined with a variety of fluorescent guests, have gained...

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Detalles Bibliográficos
Autores principales: Duan, Qunpeng, Chen, Ran, Deng, Su, Yang, Cheng, Ji, Xinxin, Qi, Gege, Li, Hui, Li, Xiaohan, Chen, Shihao, Lou, Mengen, Lu, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880063/
https://www.ncbi.nlm.nih.gov/pubmed/36711232
http://dx.doi.org/10.3389/fchem.2023.1124705
Descripción
Sumario:The widespread conversion of synthetic receptors into luminescent sensors has been achieved via the use of fluorescent-indicator displacement assays (F-IDAs). Due to their rigid structures and efficient binding affinities, cucurbit[n]urils, combined with a variety of fluorescent guests, have gained extensive utilization in fluorescent-indicator displacement assays for sensing non-fluorescent or weakly fluorescent organic compounds (analytes) in a selective and specific manner. This mini-review summarizes recent advances in the design of cucurbit[n]uril-based fluorescent-indicator displacement assays and discusses the current challenges and future prospects in this area.

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