Stromal cells support the survival of human primary chronic lymphocytic leukemia (CLL) cells through Lyn-driven extracellular vesicles

INTRODUCTION: In chronic lymphocytic leukemia (CLL), the tumor cells receive survival support from stromal cells through direct cell contact, soluble factors and extracellular vesicles (EVs). The protein tyrosine kinase Lyn is aberrantly expressed in the malignant and stromal cells in CLL tissue. We...

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Detalles Bibliográficos
Autores principales: de Oliveira, Thaís Dolzany, vom Stein, Alexander, Rebollido-Rios, Rocio, Lobastova, Liudmila, Lettau, Marcus, Janssen, Ottmar, Wagle, Prerana, Nguyen, Phuong-Hien, Hallek, Michael, Hansen, Hinrich P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880074/
https://www.ncbi.nlm.nih.gov/pubmed/36714146
http://dx.doi.org/10.3389/fmed.2022.1059028

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