Ferroptosis as a therapeutic target for inflammation-related intestinal diseases

Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxidation and resultant membrane damage. Recent research has elucidated the mechanism of ferroptosis and investigated the relationship between ferroptosis and various diseases, including...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xiaoli, Ma, Yiming, Lv, Guoqing, Wang, Hongying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880170/
https://www.ncbi.nlm.nih.gov/pubmed/36713828
http://dx.doi.org/10.3389/fphar.2023.1095366
_version_ 1784878847532990464
author Zhang, Xiaoli
Ma, Yiming
Lv, Guoqing
Wang, Hongying
author_facet Zhang, Xiaoli
Ma, Yiming
Lv, Guoqing
Wang, Hongying
author_sort Zhang, Xiaoli
collection PubMed
description Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxidation and resultant membrane damage. Recent research has elucidated the mechanism of ferroptosis and investigated the relationship between ferroptosis and various diseases, including degenerative diseases, cancer, and inflammation. Ferroptosis is associated with inflammation-related intestinal diseases such as colitis and colitis-associated cancer. New insights into the role of ferroptosis in the pathogenesis of inflammation-related gut diseases have suggested novel therapeutic targets. In this review, we summarize current information on the molecular mechanisms of ferroptosis and describe its emerging role and therapeutic potential in inflammation-related intestinal diseases.
format Online
Article
Text
id pubmed-9880170
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-98801702023-01-28 Ferroptosis as a therapeutic target for inflammation-related intestinal diseases Zhang, Xiaoli Ma, Yiming Lv, Guoqing Wang, Hongying Front Pharmacol Pharmacology Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxidation and resultant membrane damage. Recent research has elucidated the mechanism of ferroptosis and investigated the relationship between ferroptosis and various diseases, including degenerative diseases, cancer, and inflammation. Ferroptosis is associated with inflammation-related intestinal diseases such as colitis and colitis-associated cancer. New insights into the role of ferroptosis in the pathogenesis of inflammation-related gut diseases have suggested novel therapeutic targets. In this review, we summarize current information on the molecular mechanisms of ferroptosis and describe its emerging role and therapeutic potential in inflammation-related intestinal diseases. Frontiers Media S.A. 2023-01-13 /pmc/articles/PMC9880170/ /pubmed/36713828 http://dx.doi.org/10.3389/fphar.2023.1095366 Text en Copyright © 2023 Zhang, Ma, Lv and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhang, Xiaoli
Ma, Yiming
Lv, Guoqing
Wang, Hongying
Ferroptosis as a therapeutic target for inflammation-related intestinal diseases
title Ferroptosis as a therapeutic target for inflammation-related intestinal diseases
title_full Ferroptosis as a therapeutic target for inflammation-related intestinal diseases
title_fullStr Ferroptosis as a therapeutic target for inflammation-related intestinal diseases
title_full_unstemmed Ferroptosis as a therapeutic target for inflammation-related intestinal diseases
title_short Ferroptosis as a therapeutic target for inflammation-related intestinal diseases
title_sort ferroptosis as a therapeutic target for inflammation-related intestinal diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880170/
https://www.ncbi.nlm.nih.gov/pubmed/36713828
http://dx.doi.org/10.3389/fphar.2023.1095366
work_keys_str_mv AT zhangxiaoli ferroptosisasatherapeutictargetforinflammationrelatedintestinaldiseases
AT mayiming ferroptosisasatherapeutictargetforinflammationrelatedintestinaldiseases
AT lvguoqing ferroptosisasatherapeutictargetforinflammationrelatedintestinaldiseases
AT wanghongying ferroptosisasatherapeutictargetforinflammationrelatedintestinaldiseases

Ejemplares similares