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Case report: The treatment for olfactory neuroblastoma combined with leptomeningeal carcinomatosis via an ommaya reservoir

Olfactory neuroblastoma is a rare neoplasm that usually presents in the upper nasal cavity. Although its prognosis is highly unfavorable, effective treatment options are still lacking. Moreover, there is no standard treatment for patients with olfactory neuroblastoma that progressed to leptomeningea...

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Autores principales: Peng, Yichen, Kang, Xun, Jiang, Bo, Chen, Feng, Yang, Shoubo, Kang, Zhuang, Wang, Ce, Lin, Yi, Li, Shenglan, Han, Jiefei, Zhang, Botao, Zhang, Weichunbai, Li, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880206/
https://www.ncbi.nlm.nih.gov/pubmed/36713576
http://dx.doi.org/10.3389/fonc.2022.1060575
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author Peng, Yichen
Kang, Xun
Jiang, Bo
Chen, Feng
Yang, Shoubo
Kang, Zhuang
Wang, Ce
Lin, Yi
Li, Shenglan
Han, Jiefei
Zhang, Botao
Zhang, Weichunbai
Li, Wenbin
author_facet Peng, Yichen
Kang, Xun
Jiang, Bo
Chen, Feng
Yang, Shoubo
Kang, Zhuang
Wang, Ce
Lin, Yi
Li, Shenglan
Han, Jiefei
Zhang, Botao
Zhang, Weichunbai
Li, Wenbin
author_sort Peng, Yichen
collection PubMed
description Olfactory neuroblastoma is a rare neoplasm that usually presents in the upper nasal cavity. Although its prognosis is highly unfavorable, effective treatment options are still lacking. Moreover, there is no standard treatment for patients with olfactory neuroblastoma that progressed to leptomeningeal carcinomatosis. Here we report an uncommon case of a 59-year-old woman who was diagnosed with olfactory neuroblastoma and leptomeningeal carcinomatosis. For a direct delivery of the drugs to the tumor, and to avoid the impact of lumbar puncture on the patient’s quality of life, the intravenous chemotherapy plus intrathecal administration of MTX via an Ommaya reservoir was chosen. The results were striking, with the disappearance of tumor cells in the cerebrospinal fluid and the relief of the patient’s symptoms with PR. Our result indicates that chemotherapy via an Ommaya reservoir offers a new potential therapy for patients with meningeal metastases.
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spelling pubmed-98802062023-01-28 Case report: The treatment for olfactory neuroblastoma combined with leptomeningeal carcinomatosis via an ommaya reservoir Peng, Yichen Kang, Xun Jiang, Bo Chen, Feng Yang, Shoubo Kang, Zhuang Wang, Ce Lin, Yi Li, Shenglan Han, Jiefei Zhang, Botao Zhang, Weichunbai Li, Wenbin Front Oncol Oncology Olfactory neuroblastoma is a rare neoplasm that usually presents in the upper nasal cavity. Although its prognosis is highly unfavorable, effective treatment options are still lacking. Moreover, there is no standard treatment for patients with olfactory neuroblastoma that progressed to leptomeningeal carcinomatosis. Here we report an uncommon case of a 59-year-old woman who was diagnosed with olfactory neuroblastoma and leptomeningeal carcinomatosis. For a direct delivery of the drugs to the tumor, and to avoid the impact of lumbar puncture on the patient’s quality of life, the intravenous chemotherapy plus intrathecal administration of MTX via an Ommaya reservoir was chosen. The results were striking, with the disappearance of tumor cells in the cerebrospinal fluid and the relief of the patient’s symptoms with PR. Our result indicates that chemotherapy via an Ommaya reservoir offers a new potential therapy for patients with meningeal metastases. Frontiers Media S.A. 2023-01-13 /pmc/articles/PMC9880206/ /pubmed/36713576 http://dx.doi.org/10.3389/fonc.2022.1060575 Text en Copyright © 2023 Peng, Kang, Jiang, Chen, Yang, Kang, Wang, Lin, Li, Han, Zhang, Zhang and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Peng, Yichen
Kang, Xun
Jiang, Bo
Chen, Feng
Yang, Shoubo
Kang, Zhuang
Wang, Ce
Lin, Yi
Li, Shenglan
Han, Jiefei
Zhang, Botao
Zhang, Weichunbai
Li, Wenbin
Case report: The treatment for olfactory neuroblastoma combined with leptomeningeal carcinomatosis via an ommaya reservoir
title Case report: The treatment for olfactory neuroblastoma combined with leptomeningeal carcinomatosis via an ommaya reservoir
title_full Case report: The treatment for olfactory neuroblastoma combined with leptomeningeal carcinomatosis via an ommaya reservoir
title_fullStr Case report: The treatment for olfactory neuroblastoma combined with leptomeningeal carcinomatosis via an ommaya reservoir
title_full_unstemmed Case report: The treatment for olfactory neuroblastoma combined with leptomeningeal carcinomatosis via an ommaya reservoir
title_short Case report: The treatment for olfactory neuroblastoma combined with leptomeningeal carcinomatosis via an ommaya reservoir
title_sort case report: the treatment for olfactory neuroblastoma combined with leptomeningeal carcinomatosis via an ommaya reservoir
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880206/
https://www.ncbi.nlm.nih.gov/pubmed/36713576
http://dx.doi.org/10.3389/fonc.2022.1060575
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