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Protein translation paradox: Implications in translational regulation of aging
Protein translation is an essential cellular process playing key roles in growth and development. Protein translation declines over the course of age in multiple animal species, including nematodes, fruit flies, mice, rats, and even humans. In all these species, protein translation transiently peaks...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880214/ https://www.ncbi.nlm.nih.gov/pubmed/36711035 http://dx.doi.org/10.3389/fcell.2023.1129281 |
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author | Kim, Harper S. Pickering, Andrew M. |
author_facet | Kim, Harper S. Pickering, Andrew M. |
author_sort | Kim, Harper S. |
collection | PubMed |
description | Protein translation is an essential cellular process playing key roles in growth and development. Protein translation declines over the course of age in multiple animal species, including nematodes, fruit flies, mice, rats, and even humans. In all these species, protein translation transiently peaks in early adulthood with a subsequent drop over the course of age. Conversely, lifelong reductions in protein translation have been found to extend lifespan and healthspan in multiple animal models. These findings raise the protein synthesis paradox: age-related declines in protein synthesis should be detrimental, but life-long reductions in protein translation paradoxically slow down aging and prolong lifespan. This article discusses the nature of this paradox and complies an extensive body of work demonstrating protein translation as a modulator of lifespan and healthspan. |
format | Online Article Text |
id | pubmed-9880214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98802142023-01-28 Protein translation paradox: Implications in translational regulation of aging Kim, Harper S. Pickering, Andrew M. Front Cell Dev Biol Cell and Developmental Biology Protein translation is an essential cellular process playing key roles in growth and development. Protein translation declines over the course of age in multiple animal species, including nematodes, fruit flies, mice, rats, and even humans. In all these species, protein translation transiently peaks in early adulthood with a subsequent drop over the course of age. Conversely, lifelong reductions in protein translation have been found to extend lifespan and healthspan in multiple animal models. These findings raise the protein synthesis paradox: age-related declines in protein synthesis should be detrimental, but life-long reductions in protein translation paradoxically slow down aging and prolong lifespan. This article discusses the nature of this paradox and complies an extensive body of work demonstrating protein translation as a modulator of lifespan and healthspan. Frontiers Media S.A. 2023-01-13 /pmc/articles/PMC9880214/ /pubmed/36711035 http://dx.doi.org/10.3389/fcell.2023.1129281 Text en Copyright © 2023 Kim and Pickering. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Kim, Harper S. Pickering, Andrew M. Protein translation paradox: Implications in translational regulation of aging |
title | Protein translation paradox: Implications in translational regulation of aging |
title_full | Protein translation paradox: Implications in translational regulation of aging |
title_fullStr | Protein translation paradox: Implications in translational regulation of aging |
title_full_unstemmed | Protein translation paradox: Implications in translational regulation of aging |
title_short | Protein translation paradox: Implications in translational regulation of aging |
title_sort | protein translation paradox: implications in translational regulation of aging |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880214/ https://www.ncbi.nlm.nih.gov/pubmed/36711035 http://dx.doi.org/10.3389/fcell.2023.1129281 |
work_keys_str_mv | AT kimharpers proteintranslationparadoximplicationsintranslationalregulationofaging AT pickeringandrewm proteintranslationparadoximplicationsintranslationalregulationofaging |