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Living myocardial slices: Advancing arrhythmia research

Living myocardial slices (LMS) are ultrathin (150–400 µm) sections of intact myocardium that can be used as a comprehensive model for cardiac arrhythmia research. The recent introduction of biomimetic electromechanical cultivation chambers enables long-term cultivation and easy control of living myo...

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Autores principales: Amesz, Jorik H., Zhang, Lu, Everts, Bian R., De Groot, Natasja M. S., Taverne, Yannick J. H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880234/
https://www.ncbi.nlm.nih.gov/pubmed/36711023
http://dx.doi.org/10.3389/fphys.2023.1076261
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author Amesz, Jorik H.
Zhang, Lu
Everts, Bian R.
De Groot, Natasja M. S.
Taverne, Yannick J. H. J.
author_facet Amesz, Jorik H.
Zhang, Lu
Everts, Bian R.
De Groot, Natasja M. S.
Taverne, Yannick J. H. J.
author_sort Amesz, Jorik H.
collection PubMed
description Living myocardial slices (LMS) are ultrathin (150–400 µm) sections of intact myocardium that can be used as a comprehensive model for cardiac arrhythmia research. The recent introduction of biomimetic electromechanical cultivation chambers enables long-term cultivation and easy control of living myocardial slices culture conditions. The aim of this review is to present the potential of this biomimetic interface using living myocardial slices in electrophysiological studies outlining advantages, disadvantages and future perspectives of the model. Furthermore, different electrophysiological techniques and their application on living myocardial slices will be discussed. The developments of living myocardial slices in electrophysiology research will hopefully lead to future breakthroughs in the understanding of cardiac arrhythmia mechanisms and the development of novel therapeutic options.
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spelling pubmed-98802342023-01-28 Living myocardial slices: Advancing arrhythmia research Amesz, Jorik H. Zhang, Lu Everts, Bian R. De Groot, Natasja M. S. Taverne, Yannick J. H. J. Front Physiol Physiology Living myocardial slices (LMS) are ultrathin (150–400 µm) sections of intact myocardium that can be used as a comprehensive model for cardiac arrhythmia research. The recent introduction of biomimetic electromechanical cultivation chambers enables long-term cultivation and easy control of living myocardial slices culture conditions. The aim of this review is to present the potential of this biomimetic interface using living myocardial slices in electrophysiological studies outlining advantages, disadvantages and future perspectives of the model. Furthermore, different electrophysiological techniques and their application on living myocardial slices will be discussed. The developments of living myocardial slices in electrophysiology research will hopefully lead to future breakthroughs in the understanding of cardiac arrhythmia mechanisms and the development of novel therapeutic options. Frontiers Media S.A. 2023-01-13 /pmc/articles/PMC9880234/ /pubmed/36711023 http://dx.doi.org/10.3389/fphys.2023.1076261 Text en Copyright © 2023 Amesz, Zhang, Everts, De Groot and Taverne. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Amesz, Jorik H.
Zhang, Lu
Everts, Bian R.
De Groot, Natasja M. S.
Taverne, Yannick J. H. J.
Living myocardial slices: Advancing arrhythmia research
title Living myocardial slices: Advancing arrhythmia research
title_full Living myocardial slices: Advancing arrhythmia research
title_fullStr Living myocardial slices: Advancing arrhythmia research
title_full_unstemmed Living myocardial slices: Advancing arrhythmia research
title_short Living myocardial slices: Advancing arrhythmia research
title_sort living myocardial slices: advancing arrhythmia research
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880234/
https://www.ncbi.nlm.nih.gov/pubmed/36711023
http://dx.doi.org/10.3389/fphys.2023.1076261
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