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Caloric restriction induced epigenetic effects on aging
Aging is the subject of many studies, facilitating the discovery of many interventions. Epigenetic influences numerous life processes by regulating gene expression and also plays a crucial role in aging regulation. Increasing data suggests that dietary changes can alter epigenetic marks associated w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880295/ https://www.ncbi.nlm.nih.gov/pubmed/36712965 http://dx.doi.org/10.3389/fcell.2022.1079920 |
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author | Zhai, Jingfang Kongsberg, William H. Pan, Yinbo Hao, Canhua Wang, Xiaojing Sun, Jie |
author_facet | Zhai, Jingfang Kongsberg, William H. Pan, Yinbo Hao, Canhua Wang, Xiaojing Sun, Jie |
author_sort | Zhai, Jingfang |
collection | PubMed |
description | Aging is the subject of many studies, facilitating the discovery of many interventions. Epigenetic influences numerous life processes by regulating gene expression and also plays a crucial role in aging regulation. Increasing data suggests that dietary changes can alter epigenetic marks associated with aging. Caloric restriction (CR)is considered an intervention to regulate aging and prolong life span. At present, CR has made some progress by regulating signaling pathways associated with aging as well as the mechanism of action of intercellular signaling molecules against aging. In this review, we will focus on autophagy and epigenetic modifications to elaborate the molecular mechanisms by which CR delays aging by triggering autophagy, epigenetic modifications, and the interaction between the two in caloric restriction. In order to provide new ideas for the study of the mechanism of aging and delaying aging. |
format | Online Article Text |
id | pubmed-9880295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-98802952023-01-28 Caloric restriction induced epigenetic effects on aging Zhai, Jingfang Kongsberg, William H. Pan, Yinbo Hao, Canhua Wang, Xiaojing Sun, Jie Front Cell Dev Biol Cell and Developmental Biology Aging is the subject of many studies, facilitating the discovery of many interventions. Epigenetic influences numerous life processes by regulating gene expression and also plays a crucial role in aging regulation. Increasing data suggests that dietary changes can alter epigenetic marks associated with aging. Caloric restriction (CR)is considered an intervention to regulate aging and prolong life span. At present, CR has made some progress by regulating signaling pathways associated with aging as well as the mechanism of action of intercellular signaling molecules against aging. In this review, we will focus on autophagy and epigenetic modifications to elaborate the molecular mechanisms by which CR delays aging by triggering autophagy, epigenetic modifications, and the interaction between the two in caloric restriction. In order to provide new ideas for the study of the mechanism of aging and delaying aging. Frontiers Media S.A. 2023-01-13 /pmc/articles/PMC9880295/ /pubmed/36712965 http://dx.doi.org/10.3389/fcell.2022.1079920 Text en Copyright © 2023 Zhai, Kongsberg, Pan, Hao, Wang and Sun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zhai, Jingfang Kongsberg, William H. Pan, Yinbo Hao, Canhua Wang, Xiaojing Sun, Jie Caloric restriction induced epigenetic effects on aging |
title | Caloric restriction induced epigenetic effects on aging |
title_full | Caloric restriction induced epigenetic effects on aging |
title_fullStr | Caloric restriction induced epigenetic effects on aging |
title_full_unstemmed | Caloric restriction induced epigenetic effects on aging |
title_short | Caloric restriction induced epigenetic effects on aging |
title_sort | caloric restriction induced epigenetic effects on aging |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880295/ https://www.ncbi.nlm.nih.gov/pubmed/36712965 http://dx.doi.org/10.3389/fcell.2022.1079920 |
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