CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer immunotherapies. In addition to their oncolytic capacity and immunogenic influence, they can be readily engineered to express multiple large transgenes. However, the integration of multiple payloads into poxvir...

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Detalles Bibliográficos
Autores principales: Whelan, Jack T., Singaravelu, Ragunath, Wang, Fuan, Pelin, Adrian, Tamming, Levi A., Pugliese, Giuseppe, Martin, Nikolas T., Crupi, Mathieu J. F., Petryk, Julia, Austin, Bradley, He, Xiaohong, Marius, Ricardo, Duong, Jessie, Jones, Carter, Fekete, Emily E. F., Alluqmani, Nouf, Chen, Andrew, Boulton, Stephen, Huh, Michael S., Tang, Matt Y., Taha, Zaid, Scut, Elena, Diallo, Jean-Simon, Azad, Taha, Lichty, Brian D., Ilkow, Carolina S., Bell, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880309/
https://www.ncbi.nlm.nih.gov/pubmed/36713447
http://dx.doi.org/10.3389/fimmu.2022.1050250

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