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CRISPR interference for sequence-specific regulation of fibroblast growth factor receptor A in Schistosoma mansoni

Employing the flatworm parasite Schistosoma mansoni as a model, we report the first application of CRISPR interference (CRISPRi) in parasitic helminths for loss-of-function studies targeting the SmfgfrA gene which encodes the stem cell marker, fibroblast growth factor receptor A (FGFRA). SmFGFRA is...

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Detalles Bibliográficos
Autores principales:	Du, Xiaofeng, McManus, Donald P., French, Juliet D., Collinson, Natasha, Sivakumaran, Haran, MacGregor, Skye R., Fogarty, Conor E., Jones, Malcolm K., You, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880433/ https://www.ncbi.nlm.nih.gov/pubmed/36713455 http://dx.doi.org/10.3389/fimmu.2022.1105719

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