Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities

Pancreatic cancer (PC) is a malignant tumor with high malignancy that is difficult to diagnose and treat. PC is a major medical problem because of its low early diagnosis rate, high surgical mortality rate, low cure rate, and expensive related testing cost. Therefore, the significance of finding new...

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Detalles Bibliográficos
Autores principales: Liu, Dahai, Li, Jie, Qi, Fei, You, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880980/
https://www.ncbi.nlm.nih.gov/pubmed/36713527
http://dx.doi.org/10.3389/fonc.2022.1106762
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author Liu, Dahai
Li, Jie
Qi, Fei
You, Hua
author_facet Liu, Dahai
Li, Jie
Qi, Fei
You, Hua
author_sort Liu, Dahai
collection PubMed
description Pancreatic cancer (PC) is a malignant tumor with high malignancy that is difficult to diagnose and treat. PC is a major medical problem because of its low early diagnosis rate, high surgical mortality rate, low cure rate, and expensive related testing cost. Therefore, the significance of finding new markers for PC is self-evident. Semaphorins (Semas) have been shown to affect angiogenesis and lymphangiogenesis and can also directly affect the behavior of tumor cells. The expression and related action targets of its family members on PC are summarized in this review.
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spelling pubmed-98809802023-01-28 Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities Liu, Dahai Li, Jie Qi, Fei You, Hua Front Oncol Oncology Pancreatic cancer (PC) is a malignant tumor with high malignancy that is difficult to diagnose and treat. PC is a major medical problem because of its low early diagnosis rate, high surgical mortality rate, low cure rate, and expensive related testing cost. Therefore, the significance of finding new markers for PC is self-evident. Semaphorins (Semas) have been shown to affect angiogenesis and lymphangiogenesis and can also directly affect the behavior of tumor cells. The expression and related action targets of its family members on PC are summarized in this review. Frontiers Media S.A. 2023-01-13 /pmc/articles/PMC9880980/ /pubmed/36713527 http://dx.doi.org/10.3389/fonc.2022.1106762 Text en Copyright © 2023 Liu, Li, Qi and You https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liu, Dahai
Li, Jie
Qi, Fei
You, Hua
Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities
title Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities
title_full Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities
title_fullStr Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities
title_full_unstemmed Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities
title_short Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities
title_sort semaphorins and their receptors in pancreatic cancer: mechanisms and therapeutic opportunities
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880980/
https://www.ncbi.nlm.nih.gov/pubmed/36713527
http://dx.doi.org/10.3389/fonc.2022.1106762
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