Polyunsaturated Fatty Acids Mend Macrophage Transcriptome, Glycome, and Phenotype in the Patients with Neurodegenerative Diseases, Including Alzheimer’s Disease

BACKGROUND: Macrophages of healthy subjects have a pro-resolution phenotype, upload amyloid-β (Aβ) into endosomes, and degrade Aβ, whereas macrophages of patients with Alzheimer’s disease (AD) generally have a pro-inflammatory phenotype and lack energy for brain clearance of Aβ. OBJECTIVE: To clarif...

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Detalles Bibliográficos
Autores principales: Dover, Mary, Moseley, Taylor, Biskaduros, Adrienne, Paulchakrabarti, Mousumi, Hwang, Sung Hee, Hammock, Bruce, Choudhury, Biswa, Kaczor-Urbanowicz, Karolina Elżbieta, Urbanowicz, Andrzej, Morselli, Marco, Dang, Johnny, Pellegrini, Matteo, Paul, Ketema, Bentolila, Laurent A., Fiala, Milan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881025/
https://www.ncbi.nlm.nih.gov/pubmed/36373322
http://dx.doi.org/10.3233/JAD-220764

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