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Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents
Nowadays, neurodegenerative diseases (NDs), such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), represent a great challenge in different scientific fields, such as neuropharmacology, medicinal chemistry, molecular biology an...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881080/ https://www.ncbi.nlm.nih.gov/pubmed/34825873 http://dx.doi.org/10.2174/1570159X19666210712152532 |
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author | Dias Viegas, Flávia P. Gontijo, Vanessa Silva de Freitas Silva, Matheus Cristancho Ortiz, Cindy Juliet Franco, Graziella dos Reis Rosa Ernesto, Januário Tomás Damasio, Caio Miranda Fernandes Silva, Isabela Marie Campos, Thâmara Gaspar Viegas, Claudio |
author_facet | Dias Viegas, Flávia P. Gontijo, Vanessa Silva de Freitas Silva, Matheus Cristancho Ortiz, Cindy Juliet Franco, Graziella dos Reis Rosa Ernesto, Januário Tomás Damasio, Caio Miranda Fernandes Silva, Isabela Marie Campos, Thâmara Gaspar Viegas, Claudio |
author_sort | Dias Viegas, Flávia P. |
collection | PubMed |
description | Nowadays, neurodegenerative diseases (NDs), such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), represent a great challenge in different scientific fields, such as neuropharmacology, medicinal chemistry, molecular biology and medicine, as all these pathologies remain incurable, with high socio-economic impacts and high costs for governmental health services. Due to their severity and multifactorial pathophysiological complexity, the available approved drugs for clinic have not yet shown adequate effectiveness and exhibited very restricted options in the therapeutic arsenal; this highlights the need for continued drug discovery efforts in the academia and industry. In this context, natural products, such as curcumin (1), resveratrol (2) and cannabidiol (CBD, 3) have been recognized as important sources, with promising chemical entities, prototype models and starting materials for medicinal organic chemistry, as their molecular architecture, multifunctional properties and single chemical diversity could facilitate the discovery, optimization and development of innovative drug candidates with improved pharmacodynamics and pharmacokinetics compared to the known drugs and, perhaps, provide a chance for discovering novel effective drugs to combat NDs. In this review, we report the most recent efforts of medicinal chemists worldwide devoted to the exploration of curcumin (1), resveratrol (2) and cannabidiol (CBD, 3) as starting materials or privileged scaffolds in the design of multi-target directed ligands (MTDLs) with potential therapeutic properties against NDs, which have been published in the scientific literature during the last 10 years of research and are available in PubMed, SCOPUS and Web of Science databases. |
format | Online Article Text |
id | pubmed-9881080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-98810802023-02-09 Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents Dias Viegas, Flávia P. Gontijo, Vanessa Silva de Freitas Silva, Matheus Cristancho Ortiz, Cindy Juliet Franco, Graziella dos Reis Rosa Ernesto, Januário Tomás Damasio, Caio Miranda Fernandes Silva, Isabela Marie Campos, Thâmara Gaspar Viegas, Claudio Curr Neuropharmacol Neurology Nowadays, neurodegenerative diseases (NDs), such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), represent a great challenge in different scientific fields, such as neuropharmacology, medicinal chemistry, molecular biology and medicine, as all these pathologies remain incurable, with high socio-economic impacts and high costs for governmental health services. Due to their severity and multifactorial pathophysiological complexity, the available approved drugs for clinic have not yet shown adequate effectiveness and exhibited very restricted options in the therapeutic arsenal; this highlights the need for continued drug discovery efforts in the academia and industry. In this context, natural products, such as curcumin (1), resveratrol (2) and cannabidiol (CBD, 3) have been recognized as important sources, with promising chemical entities, prototype models and starting materials for medicinal organic chemistry, as their molecular architecture, multifunctional properties and single chemical diversity could facilitate the discovery, optimization and development of innovative drug candidates with improved pharmacodynamics and pharmacokinetics compared to the known drugs and, perhaps, provide a chance for discovering novel effective drugs to combat NDs. In this review, we report the most recent efforts of medicinal chemists worldwide devoted to the exploration of curcumin (1), resveratrol (2) and cannabidiol (CBD, 3) as starting materials or privileged scaffolds in the design of multi-target directed ligands (MTDLs) with potential therapeutic properties against NDs, which have been published in the scientific literature during the last 10 years of research and are available in PubMed, SCOPUS and Web of Science databases. Bentham Science Publishers 2022-07-15 2022-07-15 /pmc/articles/PMC9881080/ /pubmed/34825873 http://dx.doi.org/10.2174/1570159X19666210712152532 Text en © 2022 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Neurology Dias Viegas, Flávia P. Gontijo, Vanessa Silva de Freitas Silva, Matheus Cristancho Ortiz, Cindy Juliet Franco, Graziella dos Reis Rosa Ernesto, Januário Tomás Damasio, Caio Miranda Fernandes Silva, Isabela Marie Campos, Thâmara Gaspar Viegas, Claudio Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents |
title | Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents |
title_full | Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents |
title_fullStr | Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents |
title_full_unstemmed | Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents |
title_short | Curcumin, Resveratrol and Cannabidiol as Natural Key Prototypes in Drug Design for Neuroprotective Agents |
title_sort | curcumin, resveratrol and cannabidiol as natural key prototypes in drug design for neuroprotective agents |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881080/ https://www.ncbi.nlm.nih.gov/pubmed/34825873 http://dx.doi.org/10.2174/1570159X19666210712152532 |
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