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Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome

The number of genetic variations in the SARS-CoV-2 genome has been increasing primarily due to continuous viral mutations. Here, we report that the human APOBEC3A (A3A) cytidine deaminase plays a critical role in the induction of C-to-U substitutions in the SARS-CoV-2 genome. Bioinformatic analysis...

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Detalles Bibliográficos
Autores principales:	Nakata, Yoshihiro, Ode, Hirotaka, Kubota, Mai, Kasahara, Takaaki, Matsuoka, Kazuhiro, Sugimoto, Atsuko, Imahashi, Mayumi, Yokomaku, Yoshiyuki, Iwatani, Yasumasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881129/ https://www.ncbi.nlm.nih.gov/pubmed/36610792 http://dx.doi.org/10.1093/nar/gkac1238

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