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Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity

Double-strand DNA breaks (DSBs) are toxic to cells, and improper repair can cause chromosomal abnormalities that initiate and drive cancer progression. DNA ligases III and IV (LIG3, LIG4) have long been credited for repair of DSBs in mammals, but recent evidence suggests that DNA ligase I (LIG1) has...

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Detalles Bibliográficos
Autores principales:	McNally, Justin R, Ames, Amanda M, Admiraal, Suzanne J, O’Brien, Patrick J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881130/ https://www.ncbi.nlm.nih.gov/pubmed/36625284 http://dx.doi.org/10.1093/nar/gkac1263

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