Poison cassette exon splicing of SRSF6 regulates nuclear speckle dispersal and the response to hypoxia

Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS response to hypoxia. The SRSF6 level is strongly reduced in acute hypoxia, which serves a dual purpose: it allows for exon skipping...

Descripción completa

Detalles Bibliográficos
Autores principales: de Oliveira Freitas Machado, Camila, Schafranek, Michal, Brüggemann, Mirko, Hernández Cañás, María Clara, Keller, Mario, Di Liddo, Antonella, Brezski, Andre, Blümel, Nicole, Arnold, Benjamin, Bremm, Anja, Wittig, Ilka, Jaé, Nicolas, McNicoll, François, Dimmeler, Stefanie, Zarnack, Kathi, Müller-McNicoll, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881134/
https://www.ncbi.nlm.nih.gov/pubmed/36620874
http://dx.doi.org/10.1093/nar/gkac1225

Ejemplares similares

Ejemplares similares