Lack of a protective effect of the Tmem106b “protective SNP” in the Grn knockout mouse model for frontotemporal lobar degeneration

Genetic variants in TMEM106B are a common risk factor for frontotemporal lobar degeneration and the most important modifier of disease risk in patients with progranulin (GRN) mutations (FTLD-GRN). TMEM106B is encoding a lysosomal transmembrane protein of unknown molecular function. How it mediates i...

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Detalles Bibliográficos
Autores principales: Cabron, Anne-Sophie, Borgmeyer, Uwe, Richter, Julia, Peisker, Helga, Gutbrod, Katharina, Dörmann, Peter, Capell, Anja, Damme, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881268/
https://www.ncbi.nlm.nih.gov/pubmed/36707901
http://dx.doi.org/10.1186/s40478-023-01510-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881268/
https://www.ncbi.nlm.nih.gov/pubmed/36707901
http://dx.doi.org/10.1186/s40478-023-01510-3

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