Deletion of Tbc1d4/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia/reperfusion

BACKGROUND: Type 2 Diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease and associated with poor outcome after myocardial infarction (MI). In T2DM, cardiac metabolic flexibility, i.e. the switch between carbohydrates and lipids as energy source, is disturbed. The RabGTPase-acti...

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Detalles Bibliográficos
Autores principales: Binsch, C., Barbosa, D. M., Hansen-Dille, G., Hubert, M., Hodge, S. M., Kolasa, M., Jeruschke, K., Weiß, J., Springer, C., Gorressen, S., Fischer, J. W., Lienhard, M., Herwig, R., Börno, S., Timmermann, B., Cremer, A. L., Backes, H., Chadt, A., Al-Hasani, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881301/
https://www.ncbi.nlm.nih.gov/pubmed/36707786
http://dx.doi.org/10.1186/s12933-023-01746-2

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