In cellulo and in vivo assays for compound testing against Trypanosoma cruzi

Here, we describe a combined in cellulo and in vivo approach to identify compounds with higher potential for efficient inhibition of Trypanosoma cruzi. Phase I of in cellulo assays is designed to exclude inactive or toxic compounds, while phase II is designed for accurate IC(50), CC(50), and selecti...

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Detalles Bibliográficos
Autores principales: Guerra-Slompo, Eloise Pavão, Picchi-Constante, Gisele Fernanda Assine, Marek, Martin, Romier, Christophe, Sippl, Wolfgang, Zanchin, Nilson Ivo Tonin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881407/
https://www.ncbi.nlm.nih.gov/pubmed/36853683
http://dx.doi.org/10.1016/j.xpro.2023.102058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881407/
https://www.ncbi.nlm.nih.gov/pubmed/36853683
http://dx.doi.org/10.1016/j.xpro.2023.102058

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