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hERG Blockade Prediction by Combining Site Identification by Ligand Competitive Saturation and Physicochemical Properties
Human ether-a-go-go-related gene (hERG) potassium channel is well-known contributor to drug-induced cardiotoxicity and therefore an extremely important target when performing safety assessments of drug candidates. Ligand-based approaches in connection with quantitative structure active relationships...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881610/ https://www.ncbi.nlm.nih.gov/pubmed/36712295 http://dx.doi.org/10.3390/chemistry4030045 |