Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report

CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by an overall low response rate with frequent relapses after clinical treatment. CASE REPORT: Here, we describe the case of a 61-year-old obese female with clinically diagnosed AML who presented a complex karyotype involvi...

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Detalles Bibliográficos
Autores principales: Ornellas, Maria Helena Faria, Maioli, Maria Christina Paixão, de Lucena, Stella Beatriz Sampaio Gonçalves, Bastos, Elenice Ferreira, Chaves, Tatiana Silva, de Melo, Karina Vieira, Ribeiro-Carvalho, Marilza de Moura, Liehr, Thomas, Alves, Gilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Paulista de Medicina - APM 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881703/
https://www.ncbi.nlm.nih.gov/pubmed/28832804
http://dx.doi.org/10.1590/1516-3180.2016.0252150217
Descripción
Sumario:CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by an overall low response rate with frequent relapses after clinical treatment. CASE REPORT: Here, we describe the case of a 61-year-old obese female with clinically diagnosed AML who presented a complex karyotype involving an uncommon abnormality: ring chromosome 11. Immunophenotypic analysis confirmed the diagnosis. Classical and molecular cytogenetic analyses, using GTG banding and FISH (fluorescence in situ hybridization), revealed the presence of complex structural rearrangement involving r(11), add(12)(p13), der(5) and der(13). CONCLUSION: Molecular cytogenetic analysis is suitable for better identification and characterization of chromosomal rearrangements in AML. Case reports like this, as well as population-based studies, are necessary for understanding the karyotypic changes that occur in humans.

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