Liquid Biopsy for Guiding Treatment Decisions in Advanced Non–Small Cell Lung Cancer

Lung cancer is the leading cause of cancer-related deaths in the United States. The 5-year survival rates are poor with traditional therapy alone. New scientific advances in technology involving the human genome, including diagnostic tools to inform on tumor-derived acquired (somatic) mutations that...

Descripción completa

Detalles Bibliográficos
Autor principal: Suk, Gretchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Harborside Press LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881738/
https://www.ncbi.nlm.nih.gov/pubmed/36727019
http://dx.doi.org/10.6004/jadpro.2022.13.8.5
_version_ 1784879174407684096
author Suk, Gretchen
author_facet Suk, Gretchen
author_sort Suk, Gretchen
collection PubMed
description Lung cancer is the leading cause of cancer-related deaths in the United States. The 5-year survival rates are poor with traditional therapy alone. New scientific advances in technology involving the human genome, including diagnostic tools to inform on tumor-derived acquired (somatic) mutations that drive cancer formation, are essential to utilize. Targeting cancer cells paired with actionable drugs to shut off growth pathways has significantly improved patient survival. Obtaining mutational analysis can be performed via traditional methods such as tissue; new advances allow comparable information obtained through liquid biopsy to inform targeted treatment decision-making. Getting tissue for additional molecular analysis can pose several challenges for patients. Liquid biopsy is a minimally invasive test (typically blood) analyzed by next-generation sequencing for tumor shed to obtain actionable information for treatment decisions. Analyses between blood and tissue consistently yield high concordance, with liquid biopsy providing faster turnaround time for results than tissue. The utility of liquid biopsy is well proven but not standardized and cannot diagnose lung cancer histopathology, which requires a tissue diagnosis.
format Online
Article
Text
id pubmed-9881738
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Harborside Press LLC
record_format MEDLINE/PubMed
spelling pubmed-98817382023-01-31 Liquid Biopsy for Guiding Treatment Decisions in Advanced Non–Small Cell Lung Cancer Suk, Gretchen J Adv Pract Oncol Review Lung cancer is the leading cause of cancer-related deaths in the United States. The 5-year survival rates are poor with traditional therapy alone. New scientific advances in technology involving the human genome, including diagnostic tools to inform on tumor-derived acquired (somatic) mutations that drive cancer formation, are essential to utilize. Targeting cancer cells paired with actionable drugs to shut off growth pathways has significantly improved patient survival. Obtaining mutational analysis can be performed via traditional methods such as tissue; new advances allow comparable information obtained through liquid biopsy to inform targeted treatment decision-making. Getting tissue for additional molecular analysis can pose several challenges for patients. Liquid biopsy is a minimally invasive test (typically blood) analyzed by next-generation sequencing for tumor shed to obtain actionable information for treatment decisions. Analyses between blood and tissue consistently yield high concordance, with liquid biopsy providing faster turnaround time for results than tissue. The utility of liquid biopsy is well proven but not standardized and cannot diagnose lung cancer histopathology, which requires a tissue diagnosis. Harborside Press LLC 2022-11 2022-11-01 /pmc/articles/PMC9881738/ /pubmed/36727019 http://dx.doi.org/10.6004/jadpro.2022.13.8.5 Text en © 2022 Harborside™ https://creativecommons.org/licenses/by-nc-nd/3.0/This article is distributed under the terms of the Creative Commons Attribution Non-Commercial Non-Derivative License, which permits unrestricted non-commercial and non-derivative use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Suk, Gretchen
Liquid Biopsy for Guiding Treatment Decisions in Advanced Non–Small Cell Lung Cancer
title Liquid Biopsy for Guiding Treatment Decisions in Advanced Non–Small Cell Lung Cancer
title_full Liquid Biopsy for Guiding Treatment Decisions in Advanced Non–Small Cell Lung Cancer
title_fullStr Liquid Biopsy for Guiding Treatment Decisions in Advanced Non–Small Cell Lung Cancer
title_full_unstemmed Liquid Biopsy for Guiding Treatment Decisions in Advanced Non–Small Cell Lung Cancer
title_short Liquid Biopsy for Guiding Treatment Decisions in Advanced Non–Small Cell Lung Cancer
title_sort liquid biopsy for guiding treatment decisions in advanced non–small cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881738/
https://www.ncbi.nlm.nih.gov/pubmed/36727019
http://dx.doi.org/10.6004/jadpro.2022.13.8.5
work_keys_str_mv AT sukgretchen liquidbiopsyforguidingtreatmentdecisionsinadvancednonsmallcelllungcancer