Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection

Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms of estimates of the level of neutralizing antibodies require...

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Detalles Bibliográficos
Autores principales: Khoury, David S., Schlub, Timothy E., Cromer, Deborah, Steain, Megan, Fong, Youyi, Gilbert, Peter B., Subbarao, Kanta, Triccas, James A., Kent, Stephen J., Davenport, Miles P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881762/
https://www.ncbi.nlm.nih.gov/pubmed/36692375
http://dx.doi.org/10.3201/eid2902.221422
Descripción
Sumario:Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms of estimates of the level of neutralizing antibodies required for protection. By normalizing antibody titers, we found that study results converge on a consistent relationship between antibody levels and protection from COVID-19. This finding can be useful for planning future vaccine use, determining population immunity, and reducing the global effects of the COVID-19 pandemic

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