Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection

Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms of estimates of the level of neutralizing antibodies require...

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Autores principales: Khoury, David S., Schlub, Timothy E., Cromer, Deborah, Steain, Megan, Fong, Youyi, Gilbert, Peter B., Subbarao, Kanta, Triccas, James A., Kent, Stephen J., Davenport, Miles P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881762/
https://www.ncbi.nlm.nih.gov/pubmed/36692375
http://dx.doi.org/10.3201/eid2902.221422
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author Khoury, David S.
Schlub, Timothy E.
Cromer, Deborah
Steain, Megan
Fong, Youyi
Gilbert, Peter B.
Subbarao, Kanta
Triccas, James A.
Kent, Stephen J.
Davenport, Miles P.
author_facet Khoury, David S.
Schlub, Timothy E.
Cromer, Deborah
Steain, Megan
Fong, Youyi
Gilbert, Peter B.
Subbarao, Kanta
Triccas, James A.
Kent, Stephen J.
Davenport, Miles P.
author_sort Khoury, David S.
collection PubMed
description Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms of estimates of the level of neutralizing antibodies required for protection. By normalizing antibody titers, we found that study results converge on a consistent relationship between antibody levels and protection from COVID-19. This finding can be useful for planning future vaccine use, determining population immunity, and reducing the global effects of the COVID-19 pandemic
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spelling pubmed-98817622023-02-08 Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection Khoury, David S. Schlub, Timothy E. Cromer, Deborah Steain, Megan Fong, Youyi Gilbert, Peter B. Subbarao, Kanta Triccas, James A. Kent, Stephen J. Davenport, Miles P. Emerg Infect Dis Research Several studies have shown that neutralizing antibody levels correlate with immune protection from COVID-19 and have estimated the relationship between neutralizing antibodies and protection. However, results of these studies vary in terms of estimates of the level of neutralizing antibodies required for protection. By normalizing antibody titers, we found that study results converge on a consistent relationship between antibody levels and protection from COVID-19. This finding can be useful for planning future vaccine use, determining population immunity, and reducing the global effects of the COVID-19 pandemic Centers for Disease Control and Prevention 2023-02 /pmc/articles/PMC9881762/ /pubmed/36692375 http://dx.doi.org/10.3201/eid2902.221422 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Khoury, David S.
Schlub, Timothy E.
Cromer, Deborah
Steain, Megan
Fong, Youyi
Gilbert, Peter B.
Subbarao, Kanta
Triccas, James A.
Kent, Stephen J.
Davenport, Miles P.
Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection
title Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection
title_full Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection
title_fullStr Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection
title_full_unstemmed Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection
title_short Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection
title_sort correlates of protection, thresholds of protection, and immunobridging among persons with sars-cov-2 infection
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881762/
https://www.ncbi.nlm.nih.gov/pubmed/36692375
http://dx.doi.org/10.3201/eid2902.221422
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