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Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA
The Omicron variant of SARS-CoV-2 has become dominant in most countries and has raised significant global health concerns. As a global commerce center, New York, New York, USA, constantly faces the risk for multiple variant introductions of SARS-CoV-2. To elucidate the introduction and transmission...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881774/ https://www.ncbi.nlm.nih.gov/pubmed/36692451 http://dx.doi.org/10.3201/eid2902.220817 |
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author | Liu, Dakai Cheng, Yexiao Zhou, Hangyu Wang, Lulan Fiel, Roberto Hurtado Gruenstein, Yehudah Luo, Jean Jingzi Singh, Vishnu Konadu, Eric James, Keither Lui, Calvin Gao, Pengcheng Urban, Carl Prasad, Nishant Segal-Maurer, Sorana Wurzberger, Esther Cheng, Genhong Wu, Aiping Rodgers, William Harry |
author_facet | Liu, Dakai Cheng, Yexiao Zhou, Hangyu Wang, Lulan Fiel, Roberto Hurtado Gruenstein, Yehudah Luo, Jean Jingzi Singh, Vishnu Konadu, Eric James, Keither Lui, Calvin Gao, Pengcheng Urban, Carl Prasad, Nishant Segal-Maurer, Sorana Wurzberger, Esther Cheng, Genhong Wu, Aiping Rodgers, William Harry |
author_sort | Liu, Dakai |
collection | PubMed |
description | The Omicron variant of SARS-CoV-2 has become dominant in most countries and has raised significant global health concerns. As a global commerce center, New York, New York, USA, constantly faces the risk for multiple variant introductions of SARS-CoV-2. To elucidate the introduction and transmission of the Omicron variant in the city of New York, we created a comprehensive genomic and epidemiologic analysis of 392 Omicron virus specimens collected during November 25–December 11, 2021. We found evidence of 4 independent introductions of Omicron subclades, including the Omicron subclade BA.1.1 with defining substitution of R346K in the spike protein. The continuous genetic divergence within each Omicron subclade revealed their local community transmission and co-circulation in New York, including both household and workplace transmissions supported by epidemiologic evidence. Our study highlights the urgent need for enhanced genomic surveillance and effective response planning for better prevention and management of emerging SARS-CoV-2 variants. |
format | Online Article Text |
id | pubmed-9881774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-98817742023-02-08 Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA Liu, Dakai Cheng, Yexiao Zhou, Hangyu Wang, Lulan Fiel, Roberto Hurtado Gruenstein, Yehudah Luo, Jean Jingzi Singh, Vishnu Konadu, Eric James, Keither Lui, Calvin Gao, Pengcheng Urban, Carl Prasad, Nishant Segal-Maurer, Sorana Wurzberger, Esther Cheng, Genhong Wu, Aiping Rodgers, William Harry Emerg Infect Dis Research The Omicron variant of SARS-CoV-2 has become dominant in most countries and has raised significant global health concerns. As a global commerce center, New York, New York, USA, constantly faces the risk for multiple variant introductions of SARS-CoV-2. To elucidate the introduction and transmission of the Omicron variant in the city of New York, we created a comprehensive genomic and epidemiologic analysis of 392 Omicron virus specimens collected during November 25–December 11, 2021. We found evidence of 4 independent introductions of Omicron subclades, including the Omicron subclade BA.1.1 with defining substitution of R346K in the spike protein. The continuous genetic divergence within each Omicron subclade revealed their local community transmission and co-circulation in New York, including both household and workplace transmissions supported by epidemiologic evidence. Our study highlights the urgent need for enhanced genomic surveillance and effective response planning for better prevention and management of emerging SARS-CoV-2 variants. Centers for Disease Control and Prevention 2023-02 /pmc/articles/PMC9881774/ /pubmed/36692451 http://dx.doi.org/10.3201/eid2902.220817 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Liu, Dakai Cheng, Yexiao Zhou, Hangyu Wang, Lulan Fiel, Roberto Hurtado Gruenstein, Yehudah Luo, Jean Jingzi Singh, Vishnu Konadu, Eric James, Keither Lui, Calvin Gao, Pengcheng Urban, Carl Prasad, Nishant Segal-Maurer, Sorana Wurzberger, Esther Cheng, Genhong Wu, Aiping Rodgers, William Harry Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA |
title | Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA |
title_full | Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA |
title_fullStr | Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA |
title_full_unstemmed | Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA |
title_short | Early Introduction and Community Transmission of SARS-CoV-2 Omicron Variant, New York, New York, USA |
title_sort | early introduction and community transmission of sars-cov-2 omicron variant, new york, new york, usa |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881774/ https://www.ncbi.nlm.nih.gov/pubmed/36692451 http://dx.doi.org/10.3201/eid2902.220817 |
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