Monkeypox Virus Evolution before 2022 Outbreak

Phylogenetic analysis of monkeypox virus genomes showed statistically significant divergence and nascent subclades during the 2022 mpox outbreak. Frequency of G>A/C>T transitions has increased in recent years, probably resulting from apolipoprotein B mRNA editing enzyme catalytic polypeptide 3...

Descripción completa

Detalles Bibliográficos
Autores principales: Dumonteil, Eric, Herrera, Claudia, Sabino-Santos, Gilberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881786/
https://www.ncbi.nlm.nih.gov/pubmed/36692511
http://dx.doi.org/10.3201/eid2902.220962
Descripción
Sumario:Phylogenetic analysis of monkeypox virus genomes showed statistically significant divergence and nascent subclades during the 2022 mpox outbreak. Frequency of G>A/C>T transitions has increased in recent years, probably resulting from apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3) deaminase editing. This microevolutionary pattern most likely reflects community spread of the virus and adaptation to humans.

Ejemplares similares