Monkeypox Virus Evolution before 2022 Outbreak

Phylogenetic analysis of monkeypox virus genomes showed statistically significant divergence and nascent subclades during the 2022 mpox outbreak. Frequency of G>A/C>T transitions has increased in recent years, probably resulting from apolipoprotein B mRNA editing enzyme catalytic polypeptide 3...

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Detalles Bibliográficos
Autores principales: Dumonteil, Eric, Herrera, Claudia, Sabino-Santos, Gilberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881786/
https://www.ncbi.nlm.nih.gov/pubmed/36692511
http://dx.doi.org/10.3201/eid2902.220962
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author Dumonteil, Eric
Herrera, Claudia
Sabino-Santos, Gilberto
author_facet Dumonteil, Eric
Herrera, Claudia
Sabino-Santos, Gilberto
author_sort Dumonteil, Eric
collection PubMed
description Phylogenetic analysis of monkeypox virus genomes showed statistically significant divergence and nascent subclades during the 2022 mpox outbreak. Frequency of G>A/C>T transitions has increased in recent years, probably resulting from apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3) deaminase editing. This microevolutionary pattern most likely reflects community spread of the virus and adaptation to humans.
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spelling pubmed-98817862023-02-08 Monkeypox Virus Evolution before 2022 Outbreak Dumonteil, Eric Herrera, Claudia Sabino-Santos, Gilberto Emerg Infect Dis Research Letter Phylogenetic analysis of monkeypox virus genomes showed statistically significant divergence and nascent subclades during the 2022 mpox outbreak. Frequency of G>A/C>T transitions has increased in recent years, probably resulting from apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G (APOBEC3) deaminase editing. This microevolutionary pattern most likely reflects community spread of the virus and adaptation to humans. Centers for Disease Control and Prevention 2023-02 /pmc/articles/PMC9881786/ /pubmed/36692511 http://dx.doi.org/10.3201/eid2902.220962 Text en https://creativecommons.org/licenses/by/4.0/Emerging Infectious Diseases is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Dumonteil, Eric
Herrera, Claudia
Sabino-Santos, Gilberto
Monkeypox Virus Evolution before 2022 Outbreak
title Monkeypox Virus Evolution before 2022 Outbreak
title_full Monkeypox Virus Evolution before 2022 Outbreak
title_fullStr Monkeypox Virus Evolution before 2022 Outbreak
title_full_unstemmed Monkeypox Virus Evolution before 2022 Outbreak
title_short Monkeypox Virus Evolution before 2022 Outbreak
title_sort monkeypox virus evolution before 2022 outbreak
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881786/
https://www.ncbi.nlm.nih.gov/pubmed/36692511
http://dx.doi.org/10.3201/eid2902.220962
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