Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

While specific cell signaling pathway inhibitors have yielded great success in oncology, directly triggering cancer cell death is one of the great drug discovery challenges facing biomedical research in the era of precision oncology. Attempts to eradicate cancer cells expressing unique target protei...

Descripción completa

Detalles Bibliográficos
Autores principales: Raina, Kanak, Forbes, Chris D., Stronk, Rebecca, Rappi, Jonathan P., Eastman, Kyle J., Gerritz, Samuel W., Yu, Xinheng, Li, Hao, Bhardwaj, Amit, Forgione, Mia, Hundt, Abigail, King, Madeline P., Posner, Zoe M., Denny, Allison, McGovern, Andrew, Puleo, David E., Garvin, Ethan, Chenard, Rebekka, Zaware, Nilesh, Mousseau, James J., Macaluso, Jennifer, Martin, Michael, Bassoli, Kyle, Jones, Kelli, Garcia, Marco, Howard, Katia, Smith, Levi M., Chen, Jinshan M., De Leon, Cesar A., Hines, John, Kayser-Bricker, Katherine J., Crews, Craig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881854/
https://www.ncbi.nlm.nih.gov/pubmed/36711980
http://dx.doi.org/10.1101/2023.01.01.522436

Ejemplares similares

Ejemplares similares