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CAS12e (CASX2) CLEAVAGE OF CCR5: IMPACT OF GUIDE RNA LENGTH AND PAM SEQUENCE ON CLEAVAGE ACTIVITY

CRISPR/Cas is under development as a therapeutic tool for the cleavage, excision, and/or modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas from Streptococcus pyogenes (SpCas9) and Staphylococcus aureus (SaCas9), alternative CRISPR systems have been identified usi...

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Detalles Bibliográficos
Autores principales:	Armstrong, David A., Hudson, Taylor R., Hodge, Christine A., Hampton, Thomas H., Howell, Alexandra L., Hayden, Matthew S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881857/ https://www.ncbi.nlm.nih.gov/pubmed/36711562 http://dx.doi.org/10.1101/2023.01.02.522476

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